ORPHA:99921
Chronic graft versus host disease
Query health: suspect — Source fetch failed for trials.
Publications
11,683
Trials
—
Interventional, condition-specific
Researchers
1,501
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0020547
- UMLS:C0867389
- NCIT:C4981
Additional Mondo synonyms (2)
GVHD, chronic · graft versus host disease, chronic
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
11,683 matched papers (6,628 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot checked
Trial fetch failed or incomplete
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
11,683
11,683 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
11,683 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
6,628 in the last 10 years · low confidence
Phrase hits: 11,683 · MeSH hits: 0
Who's working on it?
1,501
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01
- 02Lee SJ9 papers · 2026
Clinical Research Division, Fred Hutchinson Cancer Center and Department of Medicine, University of Washington, Seattle, Washington.
Papers in Europe PMC - 03Pavletic SZ9 papers · 2026
Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Papers in Europe PMC - 04El Jurdi N7 papers · 2026
Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Papers in Europe PMC - 05Cowen EW6 papers · 2026
Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Papers in Europe PMC - 06Cutler C5 papers · 2026
Division of Transplantation and Cellular Therapy, Dana-Farber Cancer Institute, Boston, MA.
Papers in Europe PMC - 07Hamilton BK5 papers · 2026
Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: hamiltb2@ccf.org.
Papers in Europe PMC - 08Jędrzejczak WW5 papers · 2026
Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, ul. Banacha 1A, Warsaw, 02-097, Poland.
Papers in Europe PMC - 09Kitko CL5 papers · 2026
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.
Papers in Europe PMC - 10Mays JW5 papers · 2026
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
—
interventional trials for this specific condition
We could not load trial data for this condition right now.
Data as of 27 July 2026
low confidence
Recruiting interventional trials
From the matched ClinicalTrials.gov set
Trial data could not be loaded for this build. This is not the same as finding zero interventional trials.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Chronic graft versus host disease" OR "GVHD, chronic" OR "graft versus host disease, chronic"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
(empty)
Query health: suspect — strategies attempted: phrase; with hits: phrase
Source errors: trials: skipped ClinicalTrials.gov (--skip-trials; typically page-ceiling unmeasurable)
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (11683) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T21:49:13.768Z