ORPHA:99919
Staphylococcal toxic-shock syndrome
Also known as: Staphylococcal TSS
Publications
777
82th percentile
Trials
0
Interventional, condition-specific
Researchers
1,032
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a Staphylococcus aureus bacterial infection.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0020545
- UMLS:C3714602
Additional Mondo synonyms (3)
Staphylococcus caused toxic shock syndrome · Staphylococcus toxic shock syndrome · staphylococcal TSS
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
777 matched papers (253 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 5 for broader category toxic shock syndrome
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
777
777 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
777 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
253 in the last 10 years · high confidence · 82th percentile (publications denominator)
Phrase hits: 777 · MeSH hits: 0
Who's working on it?
1,032
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Schlievert PM6 papers · 2023
Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA Patrick-schlievert@uiowa.edu.
Papers in Europe PMC - 02Lina G5 papers · 2022
CIRI-Centre International de Recherche en Infectiologie, Team Staphylococcal Pathogenesis, Université Claude Bernard Lyon 1, INSERM, U1111, CNRS, UMR5308, ENS Lyon, 69364 Lyon CEDEX 07, France.
Papers in Europe PMC - 03Ferry T3 papers · 2015
INSERM U851, Lyon F-69008, France. tristan.ferry@univ-lyon1.fr
Papers in Europe PMC - 04Sharma H3 papers · 2019
Department of Infectious Disease, Imperial College London, London, United Kingdom h.sharma@imperial.ac.uk s.sriskandan@imperial.ac.uk.
Papers in Europe PMC - 05Vandenesch F3 papers · 2018
Faculté de Médecine Lyon Est, Université de Lyon, Domaine de la Buire, Lyon, France.
Papers in Europe PMC - 06Ahmed S2 papers · 2023
Department of Clinical Immunology & Rheumatology, Kalinga Institute of Medical Sciences (KIMS), KIIT University, Bhubaneswar, India.
Papers in Europe PMC - 07Akat H2 papers · 2023
Department of Paediatrics , Atatürk University Faculty of Medicine, Erzurum, Turkey
Papers in Europe PMC - 08Angurana SK2 papers · 2025
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Papers in Europe PMC - 09Badiou C2 papers · 2022
CIRI-Centre International de Recherche en Infectiologie, Team Staphylococcal Pathogenesis, Université Claude Bernard Lyon 1, INSERM, U1111, CNRS, UMR5308, ENS Lyon, 69364 Lyon CEDEX 07, France.
Papers in Europe PMC - 10Bansal A2 papers · 2025
Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 5 trials are registered for toxic shock syndrome, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
5 interventional trials matched toxic shock syndrome, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: toxic shock syndrome
5
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Staphylococcal toxic-shock syndrome" OR "Staphylococcal TSS" OR "Staphylococcus caused toxic shock syndrome" OR "Staphylococcus toxic shock syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Staphylococcal toxic-shock syndrome" OR "Staphylococcal TSS" OR "Staphylococcus caused toxic shock syndrome" OR "Staphylococcus toxic shock syndrome"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"toxic shock syndrome"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T06:33:30.023Z