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ORPHA:99915

Malignant granulosa cell tumor of the ovary

high confidenceDisorder

Also known as: Granulosa cell cancer · Granulosa cell malignant tumor

Publications

247

62.3th percentile

Trials

1

Interventional, condition-specific

Researchers

1,263

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare malignant sex cord stromal tumor of ovary arising from the granulosa cells of the ovary, which occurs in peri and post menopausal women, and that presents with abnormal vaginal bleeding, abdominal pain and distension. The tumor is frequently unilateral, estrogen secreting, and has a slow natural history and a tendency to relapse long after the initial diagnosis.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (18)

adult ovarian granulosa cell tumor · adult ovarian granulosa cell tumour · cancer of granulosa cell · granulosa cell cancer · granulosa cell malignant tumor · granulosa cell malignant tumour · malignant granulosa cell neoplasm · malignant granulosa cell neoplasm of ovary · malignant granulosa cell neoplasm of the ovary · malignant granulosa cell tumor of ovary · malignant granulosa cell tumor of the ovary · malignant granulosa cell tumour of ovary · malignant granulosa cell tumour of the ovary · malignant ovarian granulosa cell neoplasm · malignant ovarian granulosa cell tumor · malignant ovarian granulosa cell tumour · ovarian granulosa cell tumor of adults · ovarian granulosa cell tumour of adults

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    247 matched papers (141 in last 10 years) Source

  3. Phenotype characterisedPresent

    1 HPO annotations (e.g. Adult onset) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

1

Associated phenotypes · MONDO:0020541

  • Adult onset

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

1

Drugs / clinical candidates · MONDO_0020541

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

247

247 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

247 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

141 in the last 10 years · high confidence · 62.3th percentile (publications denominator)

Phrase hits: 247 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,263

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Young RH6 papers · 2005

    Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.

    Papers in Europe PMC
  2. 02
    Liu Y5 papers · 2025

    Diagnosis and Treatment of Breast Diseases Center.

    Papers in Europe PMC
  3. 03
    Wang Y5 papers · 2025

    School of Traditional Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100029, China. wangyun@bucm.edu.cn.

    Papers in Europe PMC
  4. 04
    Yang J5 papers · 2024

    1] Division of Pathology, and Children's National Medical Center, George Washington University School of Medicine & Health Sciences, Washington, DC, USA [2] Center for Genetic Medicine Research, Children's Research Institute, Minneapolis, MN, USA.

    Papers in Europe PMC
  5. 05
    Gao X4 papers · 2023

    Department of Gynaecology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.

    Papers in Europe PMC
  6. 06
    Scully RE4 papers · 1992
    Papers in Europe PMC
  7. 07
    Wang W4 papers · 2025

    Key Laboratory of Organ Transplantation, Key Laboratory of Combined Multi-Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

    Papers in Europe PMC
  8. 08
    Zhang Y4 papers · 2026

    Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

    Papers in Europe PMC
  9. 09
    Anderson L3 papers · 2025

    Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA.

    Papers in Europe PMC
  10. 10
    Belli M3 papers · 2021

    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting. 7 trials are registered for granulosa cell tumor, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

high confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: granulosa cell tumor

7

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 2 · after dedupe 2 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 2 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (2)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Malignant granulosa cell tumor of the ovary — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Malignant granulosa cell tumor of the ovary" OR "Malignant granulosa cell tumor of ovary" OR "Granulosa cell cancer" OR "Granulosa cell malignant tumor" OR "adult ovarian granulosa cell tumor" OR "adult ovarian granulosa cell tumour" OR "cancer of granulosa cell" OR "cancer of the granulosa cell" OR "granulosa cell malignant tumour" OR "malignant granulosa cell neoplasm" OR "malignant granulosa cell neoplasm of ovary" OR "malignant granulosa cell neoplasm of the ovary" OR "malignant granulosa cell tumour of ovary" OR "malignant granulosa cell tumour of the ovary" OR "malignant ovarian granulosa cell neoplasm" OR "malignant ovarian granulosa cell tumor" OR "malignant ovarian granulosa cell tumour" OR "ovarian granulosa cell tumor of adults" OR "ovarian granulosa cell tumor of the adults" OR "ovarian granulosa cell tumour of adults" OR "ovarian granulosa cell tumour of the adults"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Malignant granulosa cell tumor of the ovary" OR "Malignant granulosa cell tumor of ovary" OR "Granulosa cell cancer" OR "Granulosa cell malignant tumor" OR "adult ovarian granulosa cell tumor" OR "adult ovarian granulosa cell tumour" OR "cancer of granulosa cell" OR "cancer of the granulosa cell" OR "granulosa cell malignant tumour" OR "malignant granulosa cell neoplasm" OR "malignant granulosa cell neoplasm of ovary" OR "malignant granulosa cell neoplasm of the ovary" OR "malignant granulosa cell tumour of ovary" OR "malignant granulosa cell tumour of the ovary" OR "malignant ovarian granulosa cell neoplasm" OR "malignant ovarian granulosa cell tumor" OR "malignant ovarian granulosa cell tumour" OR "ovarian granulosa cell tumor of adults" OR "ovarian granulosa cell tumor of the adults" OR "ovarian granulosa cell tumour of adults" OR "ovarian granulosa cell tumour of the adults"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"granulosa cell tumor"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T06:32:24.585Z