RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:99860

Precursor B-cell acute lymphoblastic leukemia

low confidenceDisorder

Also known as: B-ALL · Precursor B-cell acute lymphoblastic leukemia/lymphoma · Precursor B-cell acute lymphocytic leukemia · Precursor B-cell acute lymphocytic leukemia/lymphoma

Publications

99,595

Trials

69

Interventional, condition-specific

Researchers

1,311

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare acute lymphoblastic leukemia characterized by infiltration of bone marrow and peripheral blood by small to medium-sized blast cells typically positive for the B-cell markers CD19, cCD79a, and cCD22. Predilection sites for extramedullary involvement are the central nervous system, lymph nodes, spleen, liver, and testes. Patients present with evidence of bone marrow failure (i. e. thrombocytopenia, anemia, and/or neutropenia) and variable leukocyte count, as well as lymphadenopathy, , , bone pain, and arthralgias.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (13)

B cell precursor type acute leukaemia · B cell precursor type acute leukemia · B-cell precursor type acute leukaemia · B-cell precursor type acute leukemia · B-precursor ALL · precursor B-cell acute lymphoblastic leukemia/lymphoma · precursor B-cell acute lymphocytic leukaemia · precursor B-cell acute lymphocytic leukemia · precursor B-cell acute lymphocytic leukemia/lymphoma · precursor B-lymphoblastic leukaemia · precursor B-lymphoblastic leukaemia (B-precursor ALL) · precursor B-lymphoblastic leukemia · precursor B-lymphoblastic leukemia (B-precursor ALL)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    99,595 matched papers (66,782 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    69 matched on ClinicalTrials.gov (38 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

99,595

99,595 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

99,595 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

66,782 in the last 10 years · low confidence

Phrase hits: 99,595 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,311

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    DeKoter RP9 papers · 2026

    Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada rdekoter@uwo.ca.

    Papers in Europe PMC
  2. 02
    Zhang L9 papers · 2026

    Department of Oncology, The General Hospital of Western Theater Command, Chengdu, China.

    Papers in Europe PMC
  3. 03
    Iansavitchous J5 papers · 2024

    Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

    Papers in Europe PMC
  4. 04
    Li Y5 papers · 2026

    Department of Pediatrics, The Third Xiang-Ya Hospital of Central South University, Changsha, China.

    Papers in Europe PMC
  5. 05
    Sams MP5 papers · 2024

    Department of Microbiology & Immunology and the Center for Human Immunology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

    Papers in Europe PMC
  6. 06
    Batista CR4 papers · 2024

    Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

    Papers in Europe PMC
  7. 07
    Chen M4 papers · 2026

    National Cancer Data Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.

    Papers in Europe PMC
  8. 08
    Li W4 papers · 2026

    Department of Pathology.

    Papers in Europe PMC
  9. 09
    Li X4 papers · 2026

    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China. lxjneuro@csu.edu.cn.

    Papers in Europe PMC
  10. 10
    Lim M4 papers · 2024

    Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

69

interventional trials for this specific condition

69 interventional trials matched this specific condition name; 38 currently recruiting in our sample. 1,418 trials are registered for acute lymphoblastic leukemia, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

69 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 97.9th percentile).

low confidence · 97.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

69 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: acute lymphoblastic leukemia

1,418

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Precursor B-cell acute lymphoblastic leukemia" OR "B-ALL" OR "Precursor B-cell acute lymphoblastic leukemia/lymphoma" OR "Precursor B-cell acute lymphocytic leukemia" OR "Precursor B-cell acute lymphocytic leukemia/lymphoma" OR "B cell precursor type acute leukaemia" OR "B cell precursor type acute leukemia" OR "B-cell precursor type acute leukaemia" OR "B-cell precursor type acute leukemia" OR "B-precursor ALL" OR "precursor B-cell acute lymphocytic leukaemia" OR "precursor B-lymphoblastic leukaemia" OR "precursor B-lymphoblastic leukaemia (B-precursor ALL)" OR "precursor B-lymphoblastic leukemia" OR "precursor B-lymphoblastic leukemia (B-precursor ALL)"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Precursor B-cell acute lymphoblastic leukemia" OR "B-ALL" OR "Precursor B-cell acute lymphoblastic leukemia/lymphoma" OR "Precursor B-cell acute lymphocytic leukemia" OR "Precursor B-cell acute lymphocytic leukemia/lymphoma" OR "B cell precursor type acute leukaemia" OR "B cell precursor type acute leukemia" OR "B-cell precursor type acute leukaemia" OR "B-cell precursor type acute leukemia" OR "B-precursor ALL" OR "precursor B-cell acute lymphocytic leukaemia" OR "precursor B-lymphoblastic leukaemia" OR "precursor B-lymphoblastic leukaemia (B-precursor ALL)" OR "precursor B-lymphoblastic leukemia" OR "precursor B-lymphoblastic leukemia (B-precursor ALL)"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 69 interventional · 8 observational · 1 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"acute lymphoblastic leukemia"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (99595) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T06:25:20.276Z