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ORPHA:99828

Dengue fever

low confidenceDisorder

Also known as: DF · Dengue virus infection

Publications

102,229

Trials

215

Interventional, condition-specific

Researchers

1,292

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (5)

Dengue · Dengue virus caused disease or disorder · Dengue virus disease or disorder · Dengue virus infectious disease · break bone fever

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    102,229 matched papers (66,218 in last 10 years) Source

  3. Phenotype characterisedPresent

    25 HPO annotations (e.g. Cerebral hemorrhage; Gastrointestinal hemorrhage; Hepatomegaly) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPartial

    1 EMA designation (none yet with FDA orphan-indication approval) — e.g. Poly[2-[(4-{[1-carboxy-2-(hexadecylcarbamoyl)ethyl]sulfanyl}-2,3-bis({2-[((2S)-2-(2-{[(2R)-2-carbamoyl-(2-{[(2S)-1-ethoxy-3-(3-hydroxy-4oxo-1,4-dihydropyridin-1-yl)-1-oxopropan-2-yl]carbamoyl}ethyl]sulfanyl}-3-{[(2S)-1-ethoxy-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)-1-oxopropan-2-yl]carbamoyl}propanamido)-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoyl ethyl ester))-methoxy]acetyl}oxy)butyl)sulfanyl]-3-(hexadecylcarbamoyl)propanoic acid]-PEG1500-ester] Source

  6. Interventional trialPresent

    215 matched on ClinicalTrials.gov (25 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

25

Associated phenotypes · MONDO:0005502

  • Cerebral hemorrhage
  • Gastrointestinal hemorrhage
  • Hepatomegaly
  • Headache
  • Gingival bleeding

Showing 5 of 25 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · no FDA orphan-indication approval yet

  • EMA Poly[2-[(4-{[1-carboxy-2-(hexadecylcarbamoyl)ethyl]sulfanyl}-2,3-bis({2-[((2S)-2-(2-{[(2R)-2-carbamoyl-(2-{[(2S)-1-ethoxy-3-(3-hydroxy-4oxo-1,4-dihydropyridin-1-yl)-1-oxopropan-2-yl]carbamoyl}ethyl]sulfanyl}-3-{[(2S)-1-ethoxy-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)-1-oxopropan-2-yl]carbamoyl}propanamido)-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoyl ethyl ester))-methoxy]acetyl}oxy)butyl)sulfanyl]-3-(hexadecylcarbamoyl)propanoic acid]-PEG1500-ester]Treatment of dengue · 16/01/2014 · PositiveEMA designation

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

20

Drugs / clinical candidates · MONDO_0005502

CTD chemicals (MyDisease.info)

11 associated chemicals · 9 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Doxycycline · therapeutic
  • hinokiflavone · therapeutic
  • Hydroxychloroquine · therapeutic
  • podocarpusflavone A · therapeutic
  • Rolitetracycline · therapeutic
  • Silver · therapeutic
  • 24-hydroxycholesterol · marker/mechanism
  • 27-hydroxycholesterol · marker/mechanism
  • cholest-5-en-3 beta,7 alpha-diol · marker/mechanism
  • F2-Isoprostanes · marker/mechanism
  • Hydroxyeicosatetraenoic Acids · marker/mechanism

Pathways: Phagosome; Tuberculosis; Measles; Adaptive Immune System; Innate Immune System; Immune System; C-type lectin receptors (CLRs); CD209 (DC-SIGN) signaling

MyDisease.info · MONDO:0005502

Literature

Is anyone studying this?

102,229

102,229 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

102,229 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

66,218 in the last 10 years · low confidence

Phrase hits: 102,229 · MeSH hits: 4,025

Open Europe PMC search

Who's working on it?

1,292

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Chen J5 papers · 2026

    Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  2. 02
    Jiang Y5 papers · 2026

    State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.

    Papers in Europe PMC
  3. 03
    Li G5 papers · 2026

    Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  4. 04
    Liu C4 papers · 2026

    The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  5. 05
    Liu Q4 papers · 2026

    Jiangxi International Travel Healthcare Center, Nanchang, China.

    Papers in Europe PMC
  6. 06
    Wang K4 papers · 2026

    The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  7. 07
    Ye B4 papers · 2026

    The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  8. 08
    Zhan S4 papers · 2026

    The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  9. 09
    Zhong M4 papers · 2026

    Guangzhou University of Chinese Medicine, Guangzhou, China.

    Papers in Europe PMC
  10. 10
    Chia PY3 papers · 2026

    National Centre for Infectious Diseases, Singapore, Singapore.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

215

interventional trials for this specific condition

215 interventional trials matched this specific condition name; 25 currently recruiting in our sample.

Data as of 9 September 2026

215 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 99.3th percentile).

low confidence · 99.3th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

215 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

84 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 44 · after dedupe 44 · already on CT.gov 0 · kept 18 · parent 0 · uncertain 12 · dropped 14 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

Uncertain / not reviewed (12)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Dengue fever — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Dengue fever" OR "Dengue virus infection" OR "Dengue" OR "Dengue virus infectious disease" OR "break bone fever") OR (MESH:"Dengue")

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Dengue

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Dengue fever" OR "Dengue virus infection" OR "Dengue" OR "Dengue virus infectious disease" OR "break bone fever"

Interventional trials matched via: both, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 215 interventional · 84 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: DF; Dengue virus caused disease or disorder; Dengue virus disease or disorder

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (102229) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T02:12:11.421Z