ORPHA:99828
Dengue fever
Also known as: DF · Dengue virus infection
Clinical definition (Orphanet)
Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).
How rare: How common this is has not been clearly measured.
Is anyone studying this?
102,226
102,226 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
102,226 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
66,215 in the last 10 years · low confidence
Is a treatment being tested?
215
trials for this specific condition
215 interventional trials matched this specific condition name; 25 currently recruiting in our sample.
Data as of 26 July 2026
215 interventional trials — more than 59.2% of diseases in the trials denominator have none at all (151 of 255; this disease is at the 98.2th percentile).
low confidence · 98.2th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
1,292
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Chen J5 papers · 2026
Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 02Jiang Y5 papers · 2026
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
Papers in Europe PMC - 03
- 04Liu C4 papers · 2026
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 05Liu Q4 papers · 2026
Jiangxi International Travel Healthcare Center, Nanchang, China.
Papers in Europe PMC - 06Wang K4 papers · 2026
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 07Ye B4 papers · 2026
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 08Zhan S4 papers · 2026
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 09Zhong M4 papers · 2026
Guangzhou University of Chinese Medicine, Guangzhou, China.
Papers in Europe PMC - 10Chia PY3 papers · 2026
National Centre for Infectious Diseases, Singapore, Singapore.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
215 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07543458·Therapeutics for Moderate and Severe Dengue
- NCT07172100·To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia
- NCT04597437·Zanamivir Treatment of Vascular Permeability in Dengue (ZAP-DENGUE)
- NCT06551844·Adaptive Dengue Antiviral Platform Trial
- NCT07600879·Effects Of A Rehabilitation Protocol On Muscle Strength, Muscle Fatigue And Postural Control In Post-Dengue And Chikungunya Patients
- NCT07678619·Smart Analysis and Decision-Making for Emerging Infectious Diseases
- NCT07712926·Phase 3b Trial To Evaluate Safety And Immune Response (Superiority) of a Two-Dose Butantan-DV Regimen And The Standard Single Dose In Dengue-Naive Children/Adolescents and Immune Response (Non-inferiority) in a Manufacturing Facility Change (DEN-06-IB)
- NCT06894901·Impact of IIT-SIT on Dengue Clusters
- NCT06859619·Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases
- NCT05631405·Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
- NCT07016321·Emetine for Viral Outbreaks (a.k.a. EVOLVE Antiviral Initiative)
- NCT06579755·A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years)
- NCT06891950·Butantan-DV Vaccine in Elderly Populations (DEN-04-IB)
- NCT06917001·Clinical Trial Evaluating Safety and Efficacy of Resomelagon on Dengue Infection (RESOVIR-2)
- NCT06747130·Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue Patients
Observational and natural-history studies
84 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06843226·A Study in Children and Teenagers to Learn if a TDV Dengue Vaccination Lowers the Chance of Hospital Stays for Dengue
- NCT06751836·Innovative Multidisciplinary Strategies for Combating Severe Dengue
- NCT07602920·Gut Leakage' in Dengue
- NCT07358910·Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
- NCT04839757·Dengue Vaccine Strategy in Children Aged 9 to 17 Years in the French Caribbean
- NCT07112846·Prospective Clinical Registry for Evaluation of Exanthematous Infections and Coinfections
- NCT07203183·Dengue - Sample Collection Study Pakistan
- NCT07409857·International Registry of Dengue Infection in Congenital Bleeding Disorders (DengueCBDR)
- NCT04486638·Dengvaxia US Pregnancy Registry
- NCT07040202·Immune Responses to Dengue and Sepsis
- NCT07000747·Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
- NCT06776692·Characterisation of Dengue Vaccine-induced Specific Immunity in Vaccinees With and Without Prior Exposure to Flavivirus Infections or Vaccination
- NCT07007585·Risk Factors for Hospitalization and Transfusion Criteria in Patients With Dengue Virus Infection
- NCT07520279·Xpert® Tropical Fever Test on GeneXpert® Edge X System
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Dengue fever" OR "Dengue virus infection" OR "Dengue" OR "Dengue virus caused disease or disorder" OR "Dengue virus disease or disorder" OR "Dengue virus infectious disease" OR "break bone fever"
MeSH descriptor terms unioned into the query: Dengue
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Dengue fever" OR "Dengue virus infection" OR "Dengue" OR "Dengue virus infectious disease" OR "break bone fever"
Interventional trials matched via: both, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 215 interventional · 84 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): MESH:D003715 UMLS:C0011311 NCIT:C34528
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: DF
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (102226) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity