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ORPHA:99826

Marburg hemorrhagic fever

low confidenceDisorder

Also known as: Green monkey disease · MHF · Marburg virus disease

Publications

1,798

Trials

12

Interventional, condition-specific

Researchers

1,201

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

Marburg disease

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,798 matched papers (1,022 in last 10 years) Source

  3. Phenotype characterisedPresent

    74 HPO annotations (e.g. Lymphadenopathy; Arthralgia; Atypical absence status epilepticus) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    12 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

74

Associated phenotypes · MONDO:0020500

  • Lymphadenopathy
  • Arthralgia
  • Atypical absence status epilepticus
  • Bloody diarrhea
  • Excessive bleeding after a venipuncture

Showing 5 of 74 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,798

1,798 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,798 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,022 in the last 10 years · low confidence

Phrase hits: 1,798 · MeSH hits: 48

Open Europe PMC search

Who's working on it?

1,201

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Muvunyi CM15 papers · 2026

    Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda. claude.muvunyi@rbc.gov.rw.

    Papers in Europe PMC
  2. 02
    Rwagasore E13 papers · 2026

    Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.

    Papers in Europe PMC
  3. 03
    Ahmed A8 papers · 2026

    Rwanda Biomedical Centre, Kigali 7162, Rwanda.

    Papers in Europe PMC
  4. 04
    Gashema P8 papers · 2026

    Rwanda National Joint Task Force Marburg, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.

    Papers in Europe PMC
  5. 05
    Ngabonziza JCS8 papers · 2026

    Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.

    Papers in Europe PMC
  6. 06
    Siddig EE8 papers · 2026

    Rwanda Biomedical Centre, Kigali 7162, Rwanda.

    Papers in Europe PMC
  7. 07
    Butera Y7 papers · 2026

    Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. yvan.butera@moh.gov.rw.

    Papers in Europe PMC
  8. 08
    Mukagatare I7 papers · 2026

    Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.

    Papers in Europe PMC
  9. 09
    Nkeshimana M7 papers · 2026

    Ministry of Health, Kigali, Rwanda.

    Papers in Europe PMC
  10. 10
    Nsanzimana S7 papers · 2026

    Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

12

interventional trials for this specific condition

12 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 60 trials are registered for hemorrhagic fever, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

12 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.2th percentile).

low confidence · 93.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

12 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: hemorrhagic fever

60

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 5 · after dedupe 5 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 5 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (5)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Marburg hemorrhagic fever — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Marburg hemorrhagic fever" OR "Green monkey disease" OR "Marburg virus disease" OR "Marburg disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Marburg Virus Disease

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Marburg hemorrhagic fever" OR "Green monkey disease" OR "Marburg virus disease" OR "Marburg disease"

Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 12 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"hemorrhagic fever"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: MHF

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1798) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T06:20:37.137Z