ORPHA:99826
Marburg hemorrhagic fever
Also known as: Green monkey disease · MHF · Marburg virus disease
Publications
1,798
Trials
12
Interventional, condition-specific
Researchers
1,201
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0020500
- MeSH:D008379
- UMLS:C0024788
- NCIT:C84883
Additional Mondo synonyms (1)
Marburg disease
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,798 matched papers (1,022 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
12 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,798
1,798 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,798 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,022 in the last 10 years · low confidence
Phrase hits: 1,798 · MeSH hits: 48
Who's working on it?
1,201
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Muvunyi CM15 papers · 2026
Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda. claude.muvunyi@rbc.gov.rw.
Papers in Europe PMC - 02Rwagasore E13 papers · 2026
Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.
Papers in Europe PMC - 03
- 04Gashema P8 papers · 2026
Rwanda National Joint Task Force Marburg, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
Papers in Europe PMC - 05Ngabonziza JCS8 papers · 2026
Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.
Papers in Europe PMC - 06
- 07Butera Y7 papers · 2026
Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda. yvan.butera@moh.gov.rw.
Papers in Europe PMC - 08Mukagatare I7 papers · 2026
Rwanda Biomedical Center, P.O. Box: 7162, Kigali, Rwanda.
Papers in Europe PMC - 09
- 10Nsanzimana S7 papers · 2026
Rwanda Joint Task Force for Marburg Virus Disease Outbreak, Ministry of Health, Rwanda Biomedical Centre, Kigali, Rwanda.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
12
interventional trials for this specific condition
12 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 60 trials are registered for hemorrhagic fever, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
12 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 92.5th percentile).
low confidence · 92.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
12 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07425821·RECRUITING·A Phase 1 Randomized, Observer-blind, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-MARV-GP Vaccine in Adults in Good General Health
Conditions: Marburg Virus Disease·Matched via name + MeSH
Broader category: hemorrhagic fever
60
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07543458·NOT YET RECRUITING·Therapeutics for Moderate and Severe Dengue
Conditions: Dengue · Severe Dengue · Mosquito-Borne Diseases · Vector Borne Diseases·Matched via name phrase
- NCT06860334·NOT YET RECRUITING·UMIT-2 - Adaptive Phase IIb Platform Trial to Determine the Efficacy and Safety of Therapeutics for CCHF
Conditions: Crimean-Congo Hemorrhagic Fever·Matched via name phrase
- NCT06799013·RECRUITING·Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
Conditions: Vaccine · Crimean-Congo Hemorrhagic Fever·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Marburg hemorrhagic fever" OR "Green monkey disease" OR "Marburg virus disease" OR "Marburg disease"
MeSH descriptor terms unioned into the query: Marburg Virus Disease
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Marburg hemorrhagic fever" OR "Green monkey disease" OR "Marburg virus disease" OR "Marburg disease"
Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 12 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"hemorrhagic fever"
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: MHF
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (1798) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-27T06:20:37.137Z