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ORPHA:99797

Anodontia

low confidenceDisorder

Publications

5,335

Trials

1

Interventional, condition-specific

Researchers

995

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

An extreme developmental dental anomaly characterized by the complete absence of all teeth.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

complete absence of teeth · developmental absence of tooth · total anodontia of permanent and deciduous teeth

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    5,335 matched papers (1,412 in last 10 years) Source

  3. Phenotype characterisedPresent

    1 HPO annotations (e.g. Anodontia) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

1

Associated phenotypes · MONDO:0008797

  • Anodontia

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

2 associated chemicals · 4 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Etretinate · marker/mechanism
  • Tretinoin · marker/mechanism

Pathways: HTLV-I infection; Extracellular matrix organization; Elastic fibre formation; Molecules associated with elastic fibres

MyDisease.info · MONDO:0008797

Literature

Is anyone studying this?

5,335

5,335 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

5,335 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,412 in the last 10 years · low confidence

Phrase hits: 5,335 · MeSH hits: 66

Open Europe PMC search

Who's working on it?

995

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wu Y4 papers · 2026

    Institute of Archaeological Science, Fudan University, Shanghai 200433, China; Department of Anthropology, University of California San Diego, La Jolla, CA 92093, USA.

    Papers in Europe PMC
  2. 02
    Cavaré A3 papers · 2026

    CNRS, MCC, PACEA, UMR 5199, université de Bordeaux, Pessac, France; UFR des sciences odontologiques, université de Bordeaux, Bordeaux, France. Electronic address: anais.cavare@u-bordeaux.fr.

    Papers in Europe PMC
  3. 03
    Chen J3 papers · 2026

    School of Stomatology, Fujian Medical University, Fuzhou, China.

    Papers in Europe PMC
  4. 04
    Srivastava VK3 papers · 2026

    Dentistry Oral Surgery and Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, 221005, India.

    Papers in Europe PMC
  5. 05
    Wang Y3 papers · 2026

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

    Papers in Europe PMC
  6. 06
    Alam M2 papers · 2023

    Department of Prosthodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.

    Papers in Europe PMC
  7. 07
    Angelakopoulos N2 papers · 2026

    Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland; Department of Forensic Dentistry, Faculdade São Leopoldo Mandic, Campinas, Brazil. Electronic address: nikolaos.angelakopoulos@unibe.ch.

    Papers in Europe PMC
  8. 08
    Aunin E2 papers · 2026

    Tree of Life Programme, Wellcome Sanger Institute, Hinxton, England, UK.

    Papers in Europe PMC
  9. 09
    Bansal R2 papers · 2026

    Dentistry Oral Surgery and Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, 221005, India.

    Papers in Europe PMC
  10. 10
    Baratto-Filho F2 papers · 2026

    School of Dentistry, Medical Faculty, University of Tuiuti of Paraná, Curitiba, Brazil.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

low confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 38 · after dedupe 38 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 38 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (38)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Anodontia — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Anodontia" OR "complete absence of teeth" OR "complete absence of the teeth" OR "developmental absence of tooth" OR "developmental absence of the tooth" OR "total anodontia of permanent and deciduous teeth" OR "total anodontia of the permanent and deciduous teeth"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Anodontia

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Anodontia" OR "complete absence of teeth" OR "complete absence of the teeth" OR "developmental absence of tooth" OR "developmental absence of the tooth" OR "total anodontia of permanent and deciduous teeth" OR "total anodontia of the permanent and deciduous teeth"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (5335) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T06:18:11.784Z