ORPHA:98815
Self-limited epilepsy with autonomic seizures
Also known as: Benign childhood occipital epilepsy, Panayiotopoulos type · Early-onset benign childhood occipital epilepsy · Panayiotopoulos syndrome · SeLEAS
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
400
78.5th percentile
Trials
0
Interventional, condition-specific
Researchers
971
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A form of rare self-limited childhood occipital characterized by focal with autonomic features, such as nausea, vomiting, pallor, and cardiorespiratory changes, in addition to visual disturbances. Patient shows a fluctuation in symptoms and awareness during the same seizure event. are typically long lasting. This syndrome is the most common cause of afebrile, nonconvulsive status epilepticus in childhood. typically begin between the ages of 3 and 6, with remission usually occurring within 2 or 3 years. They are usually infrequent, however in some patients they can be frequent or disruptive. There is no impact on neurodevelopment, unlike self-limited childhood focal epilepsies.
How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0020307
- UMLS:C0393676
Additional Mondo synonyms (3)
benign childhood occipital epilepsy, Panayiotopoulos type · early onset benign occipital epilepsy · early-onset benign childhood occipital epilepsy
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
400 matched papers (197 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
400
400 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
400 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
197 in the last 10 years · high confidence · 78.5th percentile (publications denominator)
Phrase hits: 400 · MeSH hits: 0
Who's working on it?
971
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Kobayashi K8 papers · 2019
Department of Child Neurology Dentistry and Pharmaceutical Sciences and Okayama University Hospital Okayama University Graduate School of Medicine Okayama Japan.
Papers in Europe PMC - 02Striano P7 papers · 2024
Pediatric Neurology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Papers in Europe PMC - 03Parisi P6 papers · 2022
Child Neurology and Paediatric Sleep Centre, La Sapienza University c/o Sant'Andrea Hospital, Rome, Italy.
Papers in Europe PMC - 04Yoshinaga H6 papers · 2016
Department of Child Neurology Dentistry and Pharmaceutical Sciences and Okayama University Hospital Okayama University Graduate School of Medicine Okayama Japan.
Papers in Europe PMC - 05Akiyama T5 papers · 2019
Department of Child Neurology Dentistry and Pharmaceutical Sciences and Okayama University Hospital Okayama University Graduate School of Medicine Okayama Japan.
Papers in Europe PMC - 06Oguni H5 papers · 2023
Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan. hoguni@ped.twmu.ac.jp
Papers in Europe PMC - 07Shibata T5 papers · 2018
Department of Child Neurology Dentistry and Pharmaceutical Sciences and Okayama University Hospital Okayama University Graduate School of Medicine Okayama Japan.
Papers in Europe PMC - 08Verrotti A5 papers · 2022
Department of Pediatrics, University of Perugia, Perugia, Italy.
Papers in Europe PMC - 09Demirbilek V4 papers · 2026
Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Papers in Europe PMC - 10Dervent A4 papers · 2019
Department of Child Neurology, Special Child Neurology Clinic, İstanbul, Turkey.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Self-limited epilepsy with autonomic seizures" OR "Benign childhood occipital epilepsy, Panayiotopoulos type" OR "Early-onset benign childhood occipital epilepsy" OR "Panayiotopoulos syndrome" OR "SeLEAS" OR "early onset benign occipital epilepsy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Self-limited epilepsy with autonomic seizures" OR "Benign childhood occipital epilepsy, Panayiotopoulos type" OR "Early-onset benign childhood occipital epilepsy" OR "Panayiotopoulos syndrome" OR "SeLEAS" OR "early onset benign occipital epilepsy" OR "self-limited childhood occipital epilepsy" OR "childhood-onset self-limited focal epilepsy syndrome" OR "childhood-onset epilepsy syndrome"
Recall-expansion terms: self-limited childhood occipital epilepsy, childhood-onset self-limited focal epilepsy syndrome, childhood-onset epilepsy syndrome
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T05:25:53.060Z