ORPHA:97560
Primary membranous glomerulonephritis
Also known as: Idiopathic membranous glomerulonephritis · Primary membranous nephropathy
Clinical definition (Orphanet)
A rare glomerular disease, histologically characterized by thickening of the capillary wall, with immune deposits predominantly containing IgG4 and C3 on the sub-epithelial side, and typically manifesting with nephrotic syndrome.
How rare: How common this is has not been clearly measured.
Is anyone studying this?
1,545
1,545 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
1,545 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
1,194 in the last 10 years · low confidence
Is a treatment being tested?
33
trials for this specific condition
33 interventional trials matched this specific condition name; 20 currently recruiting in our sample. 2 trials are registered for membranous glomerulonephritis, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 26 July 2026
2
trials for membranous glomerulonephritis, the broader category this belongs to
Trials registered for a broader category may or may not enrol people with this specific subtype — eligibility criteria vary, and the trial record often doesn't say. Worth raising with a clinician. How we count trials.
33 interventional trials — more than 59.2% of diseases in the trials denominator have none at all (151 of 255; this disease is at the 93.5th percentile).
low confidence · 93.5th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
1,013
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Wang Y22 papers · 2026
Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Papers in Europe PMC - 02Li X10 papers · 2026
Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Papers in Europe PMC - 03Li Y10 papers · 2026
Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Nephrology, No.16766 Jingshi Road, Jinan, Shandong 250014, China.
Papers in Europe PMC - 04Liu Y10 papers · 2026
Department of Nephrology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Papers in Europe PMC - 05Zhang Y10 papers · 2026
Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, PR China.
Papers in Europe PMC - 06Chen Y9 papers · 2026
Nephrology and Rheumatology Immunology Diagnosis and Treatment Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Papers in Europe PMC - 07Huang B9 papers · 2026
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China. jswxhb@163.com.
Papers in Europe PMC - 08Wan Q9 papers · 2026
Cambridge Research Center, AbbVie Inc, Cambridge, MA, United States.
Papers in Europe PMC - 09Sun J8 papers · 2026
Shandong Provincial Hospital, Shandong University, Jinan, China.
Papers in Europe PMC - 10Li S7 papers · 2026
Nephrology department, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai, 200082, China.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
33 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT05668403·A Phase I Clinical Study of Recombinant Humanized Anti-CD20(B-lymphocyte Antigen CD20) Monoclonal Antibody Subcutaneous Injection in the Treatment of Primary Membranous Nephropathy
- NCT07289763·Phase II Randomized, Open-label, Multicenter Clinical Study Evaluating the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of SHR-2173 Injection in Patients With Primary Membranous Nephropathy
- NCT07234474·A Phase I Study of YK012 in Primary Membranous Nephropathy
- NCT06962800·A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)
- NCT07096843·A Phase 2 Study of Budoprutug in Subjects With Primary Membranous Nephropathy
- NCT05514015·Clinical Study of Rituximab Combined With Corticosteroids or Rituximab Monotherapy in the Treatment of Primary Membranous Nephropathy
- NCT06557265·A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
- NCT03949855·Belimumab With Rituximab for Primary Membranous Nephropathy
- NCT07029139·A Study to Learn More About the Effects and Safety of JMT601 in Adults With Primary Membranous Nephropathy
- NCT06466135·Study of WAL0921 in Patients With Glomerular Kidney Diseases
- NCT06982729·Study of YK012 in Primary Membranous Nephropathy
- NCT07157787·Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)
- NCT06614985·The Efficacy and Safety of Treatment With Telitacicept in Primary Membranous Nephropathy
- NCT05800873·Evaluate The Efficacy, Safety, Pharmacokinetics And Pharmacodynamics Of EVER001
- NCT06781944·OBINOTUZUMAB Versus Cyclophosphamide + Glucocorticoids in Primary Membranous Nephropathy(Blossom Study)
Observational and natural-history studies
4 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Primary membranous glomerulonephritis" OR "Idiopathic membranous glomerulonephritis" OR "Primary membranous nephropathy" OR "membranous nephropathy - Idiopathic"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Primary membranous glomerulonephritis" OR "Idiopathic membranous glomerulonephritis" OR "Primary membranous nephropathy" OR "membranous nephropathy - Idiopathic"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 33 interventional · 4 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): OMIM:614692 UMLS:C0086445 NCIT:C123060
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (1545) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity