ORPHA:97362
Renal hypoplasia, bilateral
Clinical definition (Orphanet)
A form of renal hypoplasia characterized by bilateral abnormally small kidneys with reduced number of nephrons. Patients are usually asymptomatic but may have hypertension, some excretory functional limitations, as well as eventual chronic renal failure.
How rare: How common this is has not been clearly measured.
Is anyone studying this?
21
21 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
21 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
13 in the last 10 years · high confidence · 35th percentile (publications denominator)
Is a treatment being tested?
0
trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 26 July 2026
0
no matched trials for renal hypoplasia, the broader category this belongs to either
Parent-category matching found a broader label but no interventional trials under it. How we count trials.
No matched interventional trials. This is true for 59.2% of diseases in the trials denominator (151 of 255). Here are the researchers publishing on it.
high confidence · 29.6th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
173
Distinct author names in 21 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01CLAGETT-DAME Margaret2 papers · 2006Papers in Europe PMC
- 02DELUCA Hector F.2 papers · 2006Papers in Europe PMC
- 03FitzPatrick DR2 papers · 2011Papers in Europe PMC
- 04Harewood L2 papers · 2011
MRC Human Genetics Unit, Institute of Genetic and Molecular Medicine, Edinburgh, United Kingdom.
Papers in Europe PMC - 05PLUM Lori A.2 papers · 2006Papers in Europe PMC
- 06TADI Bulli Padmaja2 papers · 2006Papers in Europe PMC
- 07Al-Kouatly HB1 paper · 2024
Division of Maternal-Fetal Medicine, Jefferson Health, Philadelphia, New York, USA.
Papers in Europe PMC - 08Alabdulaziz LS1 paper · 2019
From the Department of Radilogy, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Papers in Europe PMC - 09Alaynick WA1 paper · 2011Papers in Europe PMC
- 10Alberman ED1 paper · 1965Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
Broader category renal hypoplasia also has no matched interventional trial. See who's working on it above — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Renal hypoplasia, bilateral"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Renal hypoplasia, bilateral"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): UMLS:C0431692
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus