ORPHA:95491
Congenital coronary artery aneurysm
Also known as: Congenital coronary aneurysm
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
106
58.8th percentile
Trials
0
Interventional, condition-specific
Researchers
619
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
coronary artery aneurysm is a rare coronary artery defined as a more than 1.5 fold the normal size dilatation of a coronary artery segment with no identified underlying inflammatory or connective tissue disease. It may be asymptomatic or may present with angina pectoris, myocardial infarction, sudden cardiac death, fistula formation, pericardial tamponade, compression of surrounding structures, or congestive heart failure.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019825
- UMLS:C0340627
Additional Mondo synonyms (1)
congenital coronary aneurysm
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
106 matched papers (66 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
106
106 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
106 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
66 in the last 10 years · high confidence · 58.8th percentile (publications denominator)
Phrase hits: 106 · MeSH hits: 0
Who's working on it?
619
Distinct author names in 106 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Amin N2 papers · 2023
Division of Pediatric Cardiology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, USA.
Papers in Europe PMC - 02Bianchini S2 papers · 2021
Department of Pediatrics, ASST Santi Paolo e Carlo Hospital, Milan, Italy.
Papers in Europe PMC - 03Bosis S2 papers · 2021
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Papers in Europe PMC - 04Castagnola E2 papers · 2021
Infectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Papers in Europe PMC - 05Chakraborty A2 papers · 2023
Division of Pediatric Cardiology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, USA. dr.abhishek.chakraborty@gmail.com.
Papers in Europe PMC - 06
- 07Denina M2 papers · 2021
Pediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Papers in Europe PMC - 08Dodi I2 papers · 2021
Emergency and General Pediatric Unit, Pietro Barilla Children's Hospital, Parma, Italy.
Papers in Europe PMC - 09Donà D2 papers · 2021
Division of Pediatric Infectious Diseases, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Papers in Europe PMC - 10Felici E2 papers · 2021
Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Congenital coronary artery aneurysm" OR "Congenital coronary aneurysm"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Congenital coronary artery aneurysm" OR "Congenital coronary aneurysm" OR "coronary artery congenital malformation" OR "coronary artery disorder"
Recall-expansion terms: coronary artery congenital malformation, coronary artery disorder
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T04:46:01.091Z