ORPHA:95427
Secondary short bowel syndrome
Publications
3
15.2th percentile
Trials
0
Interventional, condition-specific
Researchers
30
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Secondary short bowel syndrome is an intestinal failure caused by any condition that results in a functional small intestine of less than 200 cm in length and is characterized by diarrhea, nutrient malabsoption, bowel dilation and dysmobility.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019802
- UMLS:C5681579
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
3 matched papers (3 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 107 for broader category short bowel syndrome
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
3
3 papers have ever been indexed under this name. For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
3 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
3 in the last 10 years · high confidence · 15.2th percentile (publications denominator)
Phrase hits: 3 · MeSH hits: 0
Who's working on it?
30
Distinct author names in 3 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Becherucci G1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC - 02Cammarota G1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC - 03
- 04Chieppa M1 paper · 2025
Department of Experimental Medicine (DIMeS), University of Salento, 73100 Lecce, Italy.
Papers in Europe PMC - 05Coppola G1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC - 06Covello C1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC - 07Covino M1 paper · 2025
Dipartimento di Medicina e Chirugia Translazionale, Università Cattolica del S. Cuore, 00168 Rome, Italy.
Papers in Europe PMC - 08Del Gaudio A1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC - 09El-Hady HA1 paper · 2023
Department of Surgery, Faculty of Medicine, Jouf University, Saudi Arabia; Department of Surgery, Faculty of Medicine for Girls, Al-Azhar University, Egypt. Electronic address: haelhady@ju.edu.sa.
Papers in Europe PMC - 10Foscarini E1 paper · 2025
Centre for Digestive Diseases (CEMAD) and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, L.go A. Gemelli, 8, 00168 Rome, Italy.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 107 trials are registered for short bowel syndrome, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
107 interventional trials matched short bowel syndrome, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: short bowel syndrome
107
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07691125·RECRUITING·Phase IV Study of rhGH Injection in Adult Short Bowel Syndrome
Conditions: Short Bowel Syndrome (SBS) in Adults·Matched via name phrase
- NCT06904872·RECRUITING·Safety and Efficacy of Crofelemer in Adult Patients With Short Bowel Syndrome and Intestinal Failure (SBS-IF) Without Colon-in-continuity (CIC)
Conditions: Short Bowel Syndrome · Malabsorption Syndromes · Short Gut Syndrome · Post-Op Complication·Matched via name phrase
- NCT06512584·RECRUITING·Efficacy and Safety of PJ009 in Patients With Short Bowel Syndrome Requiring Parenteral Nutrition
Conditions: Short Bowel Syndrome·Matched via name phrase
- NCT06326645·RECRUITING·Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome
Conditions: Short Bowel Syndrome·Matched via name phrase
- NCT07714499·RECRUITING·Resting Energy Expenditure by Gastrointestinal Functional Status
Conditions: Intestinal Failure · Short Bowel Syndrome·Matched via name phrase
- NCT06973304·RECRUITING·A Study of Teduglutide in Chinese Adults With Short Bowel Syndrome
Conditions: Short Bowel Syndrome·Matched via name phrase
- NCT06938542·ENROLLING BY INVITATION·Palliative Care Needs of Children With Rare Diseases and Their Families
Conditions: Trisomy 13 Syndrome · Arthrogryposis Congenita Multiplex With Intestinal Atresia · Asparagine Synthetase Deficiency · CHARGE Syndrome·Matched via name phrase
- NCT05302531·RECRUITING·Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome
Conditions: Short Bowel Syndrome · Infection, Bacterial·Matched via name phrase
- NCT07530055·NOT YET RECRUITING·Role of the Microbiota in Intestinal Adaptation During Short Bowel Syndrome
Conditions: Short Bowel Syndrome (SBS)·Matched via name phrase
- NCT04775706·RECRUITING·Phase 2 Study to Assess the Safety, PK, and PD of Sonefpeglutide (HM15912) in SBS-IF Subjects
Conditions: Short Bowel Syndrome·Matched via name phrase
- NCT05432648·RECRUITING·Fiber Food Introduction in Pediatric Short Bowel Syndrome
Conditions: Short Gut Syndrome·Matched via name phrase
- NCT07197944·RECRUITING·Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
Conditions: Short Bowel Syndrome·Matched via name phrase
- NCT03530852·RECRUITING·A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
Conditions: Short Bowel Syndrome · Malabsorption·Matched via name phrase
- NCT06240065·ENROLLING BY INVITATION·Successful Fiber Food Introduction in Short Bowel Syndrome
Conditions: Short Gut Syndrome·Matched via name phrase
- NCT05535361·RECRUITING·A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel Syndrome
Conditions: Short Bowel Syndrome·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Secondary short bowel syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Secondary short bowel syndrome"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"short bowel syndrome"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T04:41:50.201Z