ORPHA:94059
Uremic pruritus
Publications
964
Trials
47
Interventional, condition-specific
Researchers
1,065
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
964 matched papers (642 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
47 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
964
964 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
964 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
642 in the last 10 years · low confidence
Phrase hits: 964 · MeSH hits: 0
Who's working on it?
1,065
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Lu PH16 papers · 2024
Department of Dermatology, MacKay Memorial Hospital, Taipei 10449, Taiwan.
Papers in Europe PMC - 02Yosipovitch G7 papers · 2025
Dr Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, FL, USA.
Papers in Europe PMC - 03Liu J6 papers · 2026
Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Papers in Europe PMC - 04Wang L6 papers · 2025
Science and Technology Industry Development Center, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
Papers in Europe PMC - 05
- 06Li Y5 papers · 2026
Department of Nephrology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Papers in Europe PMC - 07Chuo HE4 papers · 2024
Department of Dermatology, MacKay Memorial Hospital, Taipei 10449, Taiwan.
Papers in Europe PMC - 08Lai CC4 papers · 2024
Department of Medical Education, MacKay Memorial Hospital, Taipei, Taiwan.
Papers in Europe PMC - 09Li W4 papers · 2024
Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Papers in Europe PMC - 10Li X4 papers · 2026
Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
47
interventional trials for this specific condition
47 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
47 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 96.9th percentile).
low confidence · 96.9th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
47 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06579066·NOT YET RECRUITING·The Effect of Probiotics vs Activated Charcoal in the Management of CKD Patients Suffering From Uremic Pruritus.
Conditions: Chronic Kidney Disease · Uremic Pruritus·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Uremic pruritus"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Uremic pruritus"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 47 interventional · 0 observational · 1 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- No Orphanet definition and no Mondo IDs — likely taxonomy scaffolding; confidence capped at low
Ingested 2026-07-27T04:36:15.835Z