ORPHA:93964
Blepharospasm-oromandibular dystonia syndrome
Also known as: Meige dystonia · Meige syndrome
Publications
810
87.3th percentile
Trials
4
Interventional, condition-specific
Researchers
838
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A focal dystonia involving symmetrical benign essential blepharospasm (BEB) and oromandibular dystonia.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019772
- MeSH:D008538
- UMLS:C0025183
Additional Mondo synonyms (1)
Meige Syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
810 matched papers (368 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
4 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
810
810 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
810 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
368 in the last 10 years · high confidence · 87.3th percentile (publications denominator)
Phrase hits: 810 · MeSH hits: 32
Who's working on it?
838
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Liu R16 papers · 2026
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 02Ding H12 papers · 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 03Li Y10 papers · 2026
a Beijing Institute of Function Neurosurgery , Xuanwu Hospital, Capital Medical University , Xicheng , Beijing , China.
Papers in Europe PMC - 04Liu J10 papers · 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 05Liu Z10 papers · 2026
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 06Wang D9 papers · 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 07Wu Y9 papers · 2026
Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Papers in Europe PMC - 08Zhang Y9 papers · 2025
a Beijing Institute of Function Neurosurgery , Xuanwu Hospital, Capital Medical University , Xicheng , Beijing , China.
Papers in Europe PMC - 09Hao Q8 papers · 2026
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Papers in Europe PMC - 10Li J8 papers · 2025
Department of Neurosurgery, Aerospace Center Hospital, Beijing, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
4
interventional trials for this specific condition
4 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
4 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 86.7th percentile).
high confidence · 86.7th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
4 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06912282·RECRUITING·Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Conditions: Meige Syndrome·Matched via name + MeSH
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Blepharospasm-oromandibular dystonia syndrome" OR "Meige dystonia" OR "Meige syndrome"
MeSH descriptor terms unioned into the query: Meige Syndrome
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Blepharospasm-oromandibular dystonia syndrome" OR "Meige dystonia" OR "Meige syndrome"
Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 4 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T04:34:11.295Z