ORPHA:93100
Renal agenesis, unilateral
Publications
2,231
93.5th percentile
Trials
0
Interventional, condition-specific
Researchers
1,190
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A form of renal agenesis characterized by the complete absence of development of one kidney accompanied by an absent ureter.
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019636
- UMLS:C0266294
- NCIT:C101220
Additional Mondo synonyms (3)
congenital single kidney · congenital solitary kidney · unilateral renal agenesis
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
2,231 matched papers (1,161 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 2 for broader category renal agenesis
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
2,231
2,231 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
2,231 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,161 in the last 10 years · high confidence · 93.5th percentile (publications denominator)
Phrase hits: 2,231 · MeSH hits: 0
Who's working on it?
1,190
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01
- 02Guerrier D3 papers · 2026
IGDR CNRS UMR 6290, University of Rennes, Rennes, France.
Papers in Europe PMC - 03Li L3 papers · 2026
Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. lily_lucky1@163.com.
Papers in Europe PMC - 04Morcel K3 papers · 2026
Department of Obstetrics and Gynecology, CHU Brest, Brest, France.
Papers in Europe PMC - 05Szczepanska M3 papers · 2025
Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Papers in Europe PMC - 06Zhang X3 papers · 2026
Department of Otolaryngology Head and Neck Surgery, Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Papers in Europe PMC - 07Ajjemami H2 papers · 2026
Radiology, Université de Picardie Jules-Verne, Amiens, FRA.
Papers in Europe PMC - 08
- 09Alam S2 papers · 2025
Division of Urology, El Paso Children Hospital, El Paso, TX, USA.
Papers in Europe PMC - 10Amoroso A2 papers · 2025
Department of Medical Sciences, University of Turin, Turin, Italy.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 2 trials are registered for renal agenesis, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
2 interventional trials matched renal agenesis, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: renal agenesis
2
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT03723564·RECRUITING·Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Conditions: Renal Failure Congenital · Congenital Renal Anomaly Nos · Renal Agenesis and Dysgenesis · Lower Urinary Tract Obstructive Syndrome·Matched via name phrase
- NCT06728228·RECRUITING·Amnioinfusion for Fetal Renal Failure
Conditions: Multicystic Dysplastic Kidney · Polycystic Kidney Disease · Fetal Renal Anomaly · Anhydramnios·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Renal agenesis, unilateral" OR "congenital single kidney" OR "congenital solitary kidney" OR "unilateral renal agenesis"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Renal agenesis, unilateral" OR "congenital single kidney" OR "congenital solitary kidney" OR "unilateral renal agenesis"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"renal agenesis"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T04:05:51.167Z