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ORPHA:91349

Non-functioning pituitary adenoma

medium confidenceDisorder

Also known as: NFPA

Publications

896

91.6th percentile

Trials

5

Interventional, condition-specific

Researchers

1,072

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare pituitary tumor originating from normally hormone-producing cells of the adenohypophysis, characterized by a sellar or extrasellar mass manifesting with clinical signs secondary to mass effect, but without evidence for hormonal hypersecretion. Typical manifestations are visual disturbances, headaches, cranial nerve dysfunction, and hypopituitarism but the mass may also be discovered incidentally.

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (20)

functionless adenoma of pituitary · functionless adenoma of pituitary gland · functionless adenoma of the pituitary · functionless adenoma of the pituitary gland · functionless pituitary adenoma · functionless pituitary gland adenoma · non-functioning adenoma of pituitary · non-functioning adenoma of pituitary gland · non-functioning adenoma of the pituitary · non-functioning adenoma of the pituitary gland · non-functioning pituitary adenoma · non-functioning pituitary gland adenoma · non-secretory adenoma of pituitary · non-secretory adenoma of pituitary gland · non-secretory adenoma of the pituitary · non-secretory adenoma of the pituitary gland · non-secretory pituitary adenoma · non-secretory pituitary gland adenoma · nonfunctional pituitary gland adenoma · silent pituitary gland adenoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    896 matched papers (636 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    5 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

896

896 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

896 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

636 in the last 10 years · medium confidence · 91.6th percentile (publications denominator)

Phrase hits: 896 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,072

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Ghafouri-Fard S6 papers · 2024

    Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  2. 02
    Johannsson G6 papers · 2026

    Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

    Papers in Europe PMC
  3. 03
    Ragnarsson O6 papers · 2026

    Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

    Papers in Europe PMC
  4. 04
    Olsson DS5 papers · 2025

    Department of Endocrinology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden. daniel.olsson@gu.se.

    Papers in Europe PMC
  5. 05
    Skoglund T5 papers · 2026

    Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    Papers in Europe PMC
  6. 06
    Taheri M5 papers · 2023

    Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Mohammad.taheri@uni-jena.de.

    Papers in Europe PMC
  7. 07
    Wang X5 papers · 2026

    Department of Ophthalmology.

    Papers in Europe PMC
  8. 08
    Arita K4 papers · 2024

    Department of Neurosurgery, Kagoshima University, Kagoshima, Japan.

    Papers in Europe PMC
  9. 09
    Dilmaghani NA4 papers · 2024

    Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  10. 10
    Eslami S4 papers · 2024

    Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

5

interventional trials for this specific condition

5 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 410 trials are registered for adenoma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

5 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 87.9th percentile).

medium confidence · 87.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

5 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: adenoma

410

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Non-functioning pituitary adenoma" OR "functionless adenoma of pituitary" OR "functionless adenoma of the pituitary" OR "functionless adenoma of pituitary gland" OR "functionless adenoma of the pituitary gland" OR "functionless pituitary adenoma" OR "functionless pituitary gland adenoma" OR "non-functioning adenoma of pituitary" OR "non-functioning adenoma of the pituitary" OR "non-functioning adenoma of pituitary gland" OR "non-functioning adenoma of the pituitary gland" OR "non-functioning pituitary gland adenoma" OR "non-secretory adenoma of pituitary" OR "non-secretory adenoma of the pituitary" OR "non-secretory adenoma of pituitary gland" OR "non-secretory adenoma of the pituitary gland" OR "non-secretory pituitary adenoma" OR "non-secretory pituitary gland adenoma" OR "nonfunctional pituitary gland adenoma" OR "silent pituitary gland adenoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Non-functioning pituitary adenoma" OR "functionless adenoma of pituitary" OR "functionless adenoma of the pituitary" OR "functionless adenoma of pituitary gland" OR "functionless adenoma of the pituitary gland" OR "functionless pituitary adenoma" OR "functionless pituitary gland adenoma" OR "non-functioning adenoma of pituitary" OR "non-functioning adenoma of the pituitary" OR "non-functioning adenoma of pituitary gland" OR "non-functioning adenoma of the pituitary gland" OR "non-functioning pituitary gland adenoma" OR "non-secretory adenoma of pituitary" OR "non-secretory adenoma of the pituitary" OR "non-secretory adenoma of pituitary gland" OR "non-secretory adenoma of the pituitary gland" OR "non-secretory pituitary adenoma" OR "non-secretory pituitary gland adenoma" OR "nonfunctional pituitary gland adenoma" OR "silent pituitary gland adenoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 5 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"adenoma"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: NFPA

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T03:58:45.726Z