ORPHA:91349
Non-functioning pituitary adenoma
Also known as: NFPA
Publications
896
85.2th percentile
Trials
5
Interventional, condition-specific
Researchers
1,072
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare pituitary tumor originating from normally hormone-producing cells of the adenohypophysis, characterized by a sellar or extrasellar mass manifesting with clinical signs secondary to mass effect, but without evidence for hormonal hypersecretion. Typical manifestations are visual disturbances, headaches, cranial nerve dysfunction, and hypopituitarism but the mass may also be discovered incidentally.
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019613
- NCIT:C4348
Additional Mondo synonyms (20)
functionless adenoma of pituitary · functionless adenoma of pituitary gland · functionless adenoma of the pituitary · functionless adenoma of the pituitary gland · functionless pituitary adenoma · functionless pituitary gland adenoma · non-functioning adenoma of pituitary · non-functioning adenoma of pituitary gland · non-functioning adenoma of the pituitary · non-functioning adenoma of the pituitary gland · non-functioning pituitary adenoma · non-functioning pituitary gland adenoma · non-secretory adenoma of pituitary · non-secretory adenoma of pituitary gland · non-secretory adenoma of the pituitary · non-secretory adenoma of the pituitary gland · non-secretory pituitary adenoma · non-secretory pituitary gland adenoma · nonfunctional pituitary gland adenoma · silent pituitary gland adenoma
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
896 matched papers (636 in last 10 years) Source
- Phenotype characterisedPresent
58 HPO annotations (e.g. Ptosis; Increased serum testosterone level; Heteronymous hemianopia) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
5 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
58
Associated phenotypes · MONDO:0019613
- Ptosis
- Increased serum testosterone level
- Heteronymous hemianopia
- Hypogonadotropic hypogonadism
- Female hypogonadism
Showing 5 of 58 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
3
Drugs / clinical candidates · MONDO_0019613
- CABERGOLINE·phase 3
- ONZIGOLIDE·phase 2
- PASIREOTIDE·phase 2 3
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
896
896 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
896 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
636 in the last 10 years · medium confidence · 85.2th percentile (publications denominator)
Phrase hits: 896 · MeSH hits: 0
Who's working on it?
1,072
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Ghafouri-Fard S6 papers · 2024
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Papers in Europe PMC - 02Johannsson G6 papers · 2026
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Papers in Europe PMC - 03Ragnarsson O6 papers · 2026
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Papers in Europe PMC - 04Olsson DS5 papers · 2025
Department of Endocrinology, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden. daniel.olsson@gu.se.
Papers in Europe PMC - 05Skoglund T5 papers · 2026
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Papers in Europe PMC - 06Taheri M5 papers · 2023
Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Mohammad.taheri@uni-jena.de.
Papers in Europe PMC - 07
- 08Arita K4 papers · 2024
Department of Neurosurgery, Kagoshima University, Kagoshima, Japan.
Papers in Europe PMC - 09Dilmaghani NA4 papers · 2024
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Papers in Europe PMC - 10Eslami S4 papers · 2024
Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
5
interventional trials for this specific condition
5 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 410 trials are registered for adenoma, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 11 September 2026
5 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 89.2th percentile).
medium confidence · 89.2th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
5 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06163261·RECRUITING·Individualized Physical Activity or Patients With Non Functioning Pituitary Adenoma
Not reviewed·Conditions: Non-functioning Pituitary Adenoma·Matched via name phrase
Broader category: adenoma
410
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT06550908·RECRUITING·Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images
Not reviewed·Conditions: Colonic Polyp · Colon Adenoma·Matched via name phrase
- NCT04085913·ENROLLING BY INVITATION·Exparel Injection Effect on Postoperative Opioid Usage
Not reviewed·Conditions: Thyroid · Parathyroid Adenoma·Matched via name phrase
- NCT07023471·ENROLLING BY INVITATION·Artificial Intelligence-assisted Colonoscopy, Tandem Study
Not reviewed·Conditions: Artificial Intelligence (AI) · Colonoscopy Education · Adenoma Colon Polyp·Matched via name phrase
- NCT06715384·RECRUITING·Evaluation of a CAM System for Colorectal Polyp Size Measurement
Not reviewed·Conditions: Colorectal Polyp · Colorectal Adenoma·Matched via name phrase
- NCT07568366·NOT YET RECRUITING·AI in Endoscopic Transsphenoidal Surgery
Not reviewed·Conditions: Pituitary Adenoma·Matched via name phrase
- NCT07401303·NOT YET RECRUITING·Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time
Not reviewed·Conditions: Early Gastric Cancer or Gastric Adenoma·Matched via name phrase
- NCT07446543·NOT YET RECRUITING·Effect of Negative-Pressure Drainage Versus Pancreatic Duct Stenting for Preventing Pancreatitis After Endoscopic Papillectomy for Duodenal Papillary Tumors
Not reviewed·Conditions: Ampulla of Vater Neoplasms · Ampullary Adenoma · Ampullary Carcinoma·Matched via name phrase
- NCT07090304·NOT YET RECRUITING·China Colorectal Cancer Screening Trial 2 (C-Cost2)
Not reviewed·Conditions: Colorectal Cancer · Advanced Adenoma·Matched via name phrase
- NCT06297473·ENROLLING BY INVITATION·Physical Attendance Versus Telephone or Video Follow-up in Patients With Non-functioning Pituitary Tumors.
Not reviewed·Conditions: Non-Functional Pituitary Adenoma·Matched via name phrase
- NCT07097350·NOT YET RECRUITING·Transparent Cap-Assisted Colonoscopy Combined With Computer-Aided Detection in Improving the Detection Rate of Colorectal Adenomas
Not reviewed·Conditions: Colorectal Adenoma·Matched via name phrase
- NCT05912764·RECRUITING·Evaluation of Early Home Return in Patients With Enucleation of Prostate Adenoma
Not reviewed·Conditions: Adenoma·Matched via name phrase
- NCT06949891·RECRUITING·KETOgenic Diet Therapy in Patients With ACROmegaly
Not reviewed·Conditions: Acromegaly Due to Pituitary Adenoma · Ketogenic Diet · Mediterranean Diet·Matched via name phrase
- NCT06612281·RECRUITING·Evaluation of Gixam's Performance in a FIT Negative Population
Not reviewed·Conditions: Colorectal Adenoma · Colorectal Cancer (CRC) · Colorectal Cancer (CRC) Screening·Matched via name phrase
- NCT07027254·RECRUITING·PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
Not reviewed·Conditions: Primary Aldosteronism · Secondary Hypertension · Aldosterone-Producing Adenoma · Idiopathic Hyperaldosteronism·Matched via name phrase
- NCT07470580·RECRUITING·Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension
Not reviewed·Conditions: Primary Aldosteronism Due to Conn Adenoma · Radiofrequency Ablation Treatment · Adrenalectomy·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 1 · after dedupe 1 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 1 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (1)
- ctis·2023-510039-12-00·Expired·Dopamine agonist treatment of non-functioning pituitary adenomas (NFPAs) – a randomized controlled trial
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Non-functioning pituitary adenoma — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Non-functioning pituitary adenoma" OR "functionless adenoma of pituitary" OR "functionless adenoma of the pituitary" OR "functionless adenoma of pituitary gland" OR "functionless adenoma of the pituitary gland" OR "functionless pituitary adenoma" OR "functionless pituitary gland adenoma" OR "non-functioning adenoma of pituitary" OR "non-functioning adenoma of the pituitary" OR "non-functioning adenoma of pituitary gland" OR "non-functioning adenoma of the pituitary gland" OR "non-functioning pituitary gland adenoma" OR "non-secretory adenoma of pituitary" OR "non-secretory adenoma of the pituitary" OR "non-secretory adenoma of pituitary gland" OR "non-secretory adenoma of the pituitary gland" OR "non-secretory pituitary adenoma" OR "non-secretory pituitary gland adenoma" OR "nonfunctional pituitary gland adenoma" OR "silent pituitary gland adenoma"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Non-functioning pituitary adenoma" OR "functionless adenoma of pituitary" OR "functionless adenoma of the pituitary" OR "functionless adenoma of pituitary gland" OR "functionless adenoma of the pituitary gland" OR "functionless pituitary adenoma" OR "functionless pituitary gland adenoma" OR "non-functioning adenoma of pituitary" OR "non-functioning adenoma of the pituitary" OR "non-functioning adenoma of pituitary gland" OR "non-functioning adenoma of the pituitary gland" OR "non-functioning pituitary gland adenoma" OR "non-secretory adenoma of pituitary" OR "non-secretory adenoma of the pituitary" OR "non-secretory adenoma of pituitary gland" OR "non-secretory adenoma of the pituitary gland" OR "non-secretory pituitary adenoma" OR "non-secretory pituitary gland adenoma" OR "nonfunctional pituitary gland adenoma" OR "silent pituitary gland adenoma"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 5 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"adenoma"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: NFPA
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T03:58:45.726Z