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ORPHA:91347

TSH-secreting pituitary adenoma

high confidenceDisorder

Also known as: Thyrotroph adenoma · Pituitary thyrotrophic adenoma · TSH-oma · Thyroid stimulating hormone-secreting pituitary adenoma

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

973

91.1th percentile

Trials

0

Interventional, condition-specific

Researchers

938

Distinct authors in sample

Gene link

—

Readiness

1/6

Stages with a signal

Clinical definition (Orphanet)

A rare, functioning, pituitary adenoma characterized by the presence of a pituitary mass associated with high levels of circulating, free, thyroid hormones in conjunction with normal to high levels of TSH and unresponsiveness of TSH levels to TRH stimulation and T3 suppression tests, typically manifesting with signs and symptoms of mild to moderate hyperthyroidism (e.g. goiter (most frequently observed), palpitation, excessive sweating, arrhythmia, weight loss, tremor) and/or tumor mass effect (such as headache, visual field defects, hypopituitarism). Occasionally, cosecretion of prolactin and/or growth hormone may cause galactorrhea and/or acromegaly.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (35)

TSH producing adenoma of pituitary · TSH producing adenoma of pituitary gland · TSH producing adenoma of the pituitary · TSH producing adenoma of the pituitary gland · TSH producing pituitary adenoma · TSH producing pituitary gland adenoma · TSH secreting adenoma of pituitary · TSH secreting adenoma of pituitary gland · TSH secreting adenoma of the pituitary · TSH secreting adenoma of the pituitary gland · TSH secreting pituitary adenoma · TSH secreting pituitary gland adenoma · TSH-producing adenoma · TSH-producing pituitary gland adenoma · TSHoma · pituitary thyrotrophic adenoma · thyroid stimulating hormone producing adenoma of pituitary · thyroid stimulating hormone producing adenoma of pituitary gland · thyroid stimulating hormone producing adenoma of the pituitary · thyroid stimulating hormone producing adenoma of the pituitary gland · thyroid stimulating hormone producing pituitary adenoma · thyroid stimulating hormone producing pituitary gland adenoma · thyroid stimulating hormone secreting adenoma of pituitary · thyroid stimulating hormone secreting adenoma of pituitary gland · thyroid stimulating hormone secreting adenoma of the pituitary · thyroid stimulating hormone secreting adenoma of the pituitary gland · thyroid stimulating hormone secreting pituitary adenoma · thyroid stimulating hormone secreting pituitary gland adenoma · thyroid stimulating hormone-producing adenoma · thyroid stimulating hormone-secreting pituitary adenoma · thyrotrope adenoma · thyrotroph adenoma · thyrotrophic adenoma · thyrotropin producing pituitary gland adenoma · thyrotropinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

1/6 stages with a signal

Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    973 matched papers (576 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialNot found

    No matched interventional trial under our ClinicalTrials.gov rules

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

973

973 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

973 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

576 in the last 10 years · high confidence · 91.1th percentile (publications denominator)

Phrase hits: 973 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

938

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Li Y7 papers · 2026

    Department of Pathology, Nanyang Central Hospital, Nanyang, Henan, China.

    Papers in Europe PMC
  2. 02
    Liu J7 papers · 2026

    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

    Papers in Europe PMC
  3. 03
    Chai X5 papers · 2026

    Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

    Papers in Europe PMC
  4. 04
    Kim SH5 papers · 2021

    Institute of Endocrine Research, Yonsei University College of Medicine, Seoul 03722, Korea.

    Papers in Europe PMC
  5. 05
    Lian X5 papers · 2026

    Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

    Papers in Europe PMC
  6. 06
    Nishioka H5 papers · 2025

    Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan.

    Papers in Europe PMC
  7. 07
    Wang X5 papers · 2026

    Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Chang Chun St, Beijing, 100053, China.

    Papers in Europe PMC
  8. 08
    Fujio S4 papers · 2021

    Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University.

    Papers in Europe PMC
  9. 09
    Gurnell M4 papers · 2024

    Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

    Papers in Europe PMC
  10. 10
    Refetoff S4 papers · 2024

    Departments of Medicine, Pediatrics and Committee on Genetics, The University of Chicago, Chicago, IL, United States.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

high confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"TSH-secreting pituitary adenoma" OR "Thyrotroph adenoma" OR "Pituitary thyrotrophic adenoma" OR "TSH-oma" OR "Thyroid stimulating hormone-secreting pituitary adenoma" OR "TSH producing adenoma of pituitary" OR "TSH producing adenoma of the pituitary" OR "TSH producing adenoma of pituitary gland" OR "TSH producing adenoma of the pituitary gland" OR "TSH producing pituitary adenoma" OR "TSH producing pituitary gland adenoma" OR "TSH secreting adenoma of pituitary" OR "TSH secreting adenoma of the pituitary" OR "TSH secreting adenoma of pituitary gland" OR "TSH secreting adenoma of the pituitary gland" OR "TSH secreting pituitary adenoma" OR "TSH secreting pituitary gland adenoma" OR "TSH-producing adenoma" OR "TSH-producing pituitary gland adenoma" OR "TSHoma" OR "thyroid stimulating hormone producing adenoma of pituitary" OR "thyroid stimulating hormone producing adenoma of the pituitary" OR "thyroid stimulating hormone producing adenoma of pituitary gland" OR "thyroid stimulating hormone producing adenoma of the pituitary gland" OR "thyroid stimulating hormone producing pituitary adenoma" OR "thyroid stimulating hormone producing pituitary gland adenoma" OR "thyroid stimulating hormone secreting adenoma of pituitary" OR "thyroid stimulating hormone secreting adenoma of the pituitary" OR "thyroid stimulating hormone secreting adenoma of pituitary gland" OR "thyroid stimulating hormone secreting adenoma of the pituitary gland" OR "thyroid stimulating hormone secreting pituitary adenoma" OR "thyroid stimulating hormone secreting pituitary gland adenoma" OR "thyroid stimulating hormone-producing adenoma" OR "thyrotrope adenoma" OR "thyrotrophic adenoma" OR "thyrotropin producing pituitary gland adenoma" OR "thyrotropinoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"TSH-secreting pituitary adenoma" OR "Thyrotroph adenoma" OR "Pituitary thyrotrophic adenoma" OR "TSH-oma" OR "Thyroid stimulating hormone-secreting pituitary adenoma" OR "TSH producing adenoma of pituitary" OR "TSH producing adenoma of the pituitary" OR "TSH producing adenoma of pituitary gland" OR "TSH producing adenoma of the pituitary gland" OR "TSH producing pituitary adenoma" OR "TSH producing pituitary gland adenoma" OR "TSH secreting adenoma of pituitary" OR "TSH secreting adenoma of the pituitary" OR "TSH secreting adenoma of pituitary gland" OR "TSH secreting adenoma of the pituitary gland" OR "TSH secreting pituitary adenoma" OR "TSH secreting pituitary gland adenoma" OR "TSH-producing adenoma" OR "TSH-producing pituitary gland adenoma" OR "TSHoma" OR "thyroid stimulating hormone producing adenoma of pituitary" OR "thyroid stimulating hormone producing adenoma of the pituitary" OR "thyroid stimulating hormone producing adenoma of pituitary gland" OR "thyroid stimulating hormone producing adenoma of the pituitary gland" OR "thyroid stimulating hormone producing pituitary adenoma" OR "thyroid stimulating hormone producing pituitary gland adenoma" OR "thyroid stimulating hormone secreting adenoma of pituitary" OR "thyroid stimulating hormone secreting adenoma of the pituitary" OR "thyroid stimulating hormone secreting adenoma of pituitary gland" OR "thyroid stimulating hormone secreting adenoma of the pituitary gland" OR "thyroid stimulating hormone secreting pituitary adenoma" OR "thyroid stimulating hormone secreting pituitary gland adenoma" OR "thyroid stimulating hormone-producing adenoma" OR "thyrotrope adenoma" OR "thyrotrophic adenoma" OR "thyrotropin producing pituitary gland adenoma" OR "thyrotropinoma" OR "TSH producing pituitary tumor" OR "functioning pituitary gland adenoma"

Recall-expansion terms: TSH producing pituitary tumor, functioning pituitary gland adenoma

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T03:58:18.114Z