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ORPHA:90033

Autoimmune hemolytic anemia, warm type

medium confidenceDisorder

Also known as: Warm AIHA · wAHA · wAIHA

Publications

1,116

86.7th percentile

Trials

25

Interventional, condition-specific

Researchers

989

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Warm autoimmune hemolytic anemia is the most common form of autoimmune hemolytic anemia defined by the presence of warm autoantibodies against red blood cells (autoantibodies that are active at temperatures between 37-40°C).

How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

Warm Autoimmune Hemolytic Anemia · warm AIHA

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,116 matched papers (874 in last 10 years) Source

  3. Phenotype characterisedPresent

    27 HPO annotations (e.g. Fatigue; Splenomegaly; Reticulocytosis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    25 matched on ClinicalTrials.gov (7 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

27

Associated phenotypes · MONDO:0019532

  • Fatigue
  • Splenomegaly
  • Reticulocytosis
  • Palpitations
  • Hemoglobinuria

Showing 5 of 27 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,116

1,116 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,116 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

874 in the last 10 years · medium confidence · 86.7th percentile (publications denominator)

Phrase hits: 1,116 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

989

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Fattizzo B16 papers · 2026

    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, SC Ematologia, Milan, Italy.

    Papers in Europe PMC
  2. 02
    Barcellini W15 papers · 2026

    Department of Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

    Papers in Europe PMC
  3. 03
    Murakhovskaya I9 papers · 2026

    Department of Hematology and Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

    Papers in Europe PMC
  4. 04
    Branch DR5 papers · 2024

    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

    Papers in Europe PMC
  5. 05
    Leon A5 papers · 2025

    Johnson & Johnson, Spring House, PA, USA.

    Papers in Europe PMC
  6. 06
    Yang C5 papers · 2026

    Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China.

    Papers in Europe PMC
  7. 07
    Chen M4 papers · 2026

    Department of Hematology, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing, China.

    Papers in Europe PMC
  8. 08
    Crivera C4 papers · 2025

    Janssen Global Services, LLC, Horsham, PA, United States

    Papers in Europe PMC
  9. 09
    Michel M4 papers · 2024

    Department of Internal Medicine, National Referral Center for Adult Immune Cytopenias Henri Mondor University Hospital, Service de Medecine Interne, CHU Hopital Henri-Mondor, Assistance Publique Hôpitaux de Paris, Université Paris-Est Créteil, 51 Av du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France. Electronic address: marc.michel2@aphp.fr.

    Papers in Europe PMC
  10. 10
    Mitrović M4 papers · 2023

    Clinic of Hematology, University Clinical Center of Serbia, Belgrade, Serbia.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

25

interventional trials for this specific condition

25 interventional trials matched this specific condition name; 7 currently recruiting in our sample. 47 trials are registered for autoimmune hemolytic anemia, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 9 September 2026

25 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.5th percentile).

medium confidence · 95.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

25 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: autoimmune hemolytic anemia

47

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 15 · after dedupe 15 · already on CT.gov 0 · kept 7 · parent 1 · uncertain 5 · dropped 2 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

Broader / parent-category hits (1)
Uncertain / not reviewed (5)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Autoimmune hemolytic anemia, warm type — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Autoimmune hemolytic anemia, warm type" OR "Warm AIHA" OR "wAIHA" OR "Warm Autoimmune Hemolytic Anemia"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Autoimmune hemolytic anemia, warm type" OR "Warm AIHA" OR "wAIHA" OR "Warm Autoimmune Hemolytic Anemia"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 25 interventional · 1 observational · 1 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"autoimmune hemolytic anemia"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: wAHA

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T01:52:17.377Z