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ORPHA:86850

Myeloid sarcoma

low confidenceDisorder

Also known as: Chloroma · Extramedullary myeloid tumor · Granulocytic sarcoma

Publications

5,715

Trials

12

Interventional, condition-specific

Researchers

1,169

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Myeloid sarcoma is a rare solid tumor of the myelogenous cells occurring in an extramedullary site.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (5)

chloroma · extramedullary myeloid tumor · extramedullary myeloid tumour · myeloid sarcoma · sarcoma, myeloid, malignant

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    5,715 matched papers (2,473 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    12 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

5,715

5,715 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

5,715 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

2,473 in the last 10 years · low confidence

Phrase hits: 5,714 · MeSH hits: 12

Open Europe PMC search

Who's working on it?

1,169

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Liu Y5 papers · 2026

    Hematology Oncology Center, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding Key Laboratory of Precision Medicine for Pediatric Hematology Oncology, National Center for Children's Health in Baoding, Baoding, 071000, China.

    Papers in Europe PMC
  2. 02
    Wang X5 papers · 2026

    Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

    Papers in Europe PMC
  3. 03
    Zhang Y5 papers · 2026

    West China Hospital, Sichuan University, Chengdu, China.

    Papers in Europe PMC
  4. 04
    He Y3 papers · 2025

    Department of Clinical and Experimental Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.

    Papers in Europe PMC
  5. 05
    Li Z3 papers · 2026

    The Ohio State University Columbus, OH United States.

    Papers in Europe PMC
  6. 06
    Loghavi S3 papers · 2026

    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    Papers in Europe PMC
  7. 07
    Thapa S3 papers · 2026

    The University of Oklahoma College of Medicine, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd #357, Oklahoma City, OK 73104, USA.

    Papers in Europe PMC
  8. 08
    Yang J3 papers · 2025

    Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine Westlake University Hangzhou Zhejiang China.

    Papers in Europe PMC
  9. 09
    Abaza H2 papers · 2026

    The Ohio State University Wexner Medical Center Columbus, Ohio United States.

    Papers in Europe PMC
  10. 10
    Abiko K2 papers · 2025

    2Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Ishikawa, 920-8641, Japan.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

12

interventional trials for this specific condition

12 interventional trials matched this specific condition name; 4 currently recruiting in our sample. 1,643 trials are registered for sarcoma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

12 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 92.5th percentile).

low confidence · 92.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

12 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: sarcoma

1,643

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Myeloid sarcoma" OR "Chloroma" OR "Extramedullary myeloid tumor" OR "Granulocytic sarcoma" OR "extramedullary myeloid tumour" OR "sarcoma, myeloid, malignant"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Sarcoma, Myeloid

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Myeloid sarcoma" OR "Chloroma" OR "Extramedullary myeloid tumor" OR "Granulocytic sarcoma" OR "extramedullary myeloid tumour" OR "sarcoma, myeloid, malignant" OR "Sarcoma, Myeloid"

Interventional trials matched via: phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 12 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"sarcoma"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (5715) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T03:11:58.787Z