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ORPHA:85436

Psoriasis-related juvenile idiopathic arthritis

medium confidenceDisorder

Also known as: Juvenile psoriatic arthritis · Psoriasis-related JIA

Publications

391

73.1th percentile

Trials

12

Interventional, condition-specific

Researchers

1,206

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare pediatric inflammatory rheumatic disease characterized by the presence of arthritis accompanied by either psoriasis or at least two of the following supporting features; presence of nail pitting, onycholysis, dactylitis, or a family history of psoriasis in a first degree relative. Patients are younger than 16 years of age and the disease lasts longer than 6 weeks.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

JPsA · juvenile psoriatic arthritis · psoriasis-related JIA

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    391 matched papers (268 in last 10 years) Source

  3. Phenotype characterisedPresent

    29 HPO annotations (e.g. Pruritus; Antinuclear antibody positivity; Psoriasiform dermatitis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    12 matched on ClinicalTrials.gov (6 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

29

Associated phenotypes · MONDO:0019436

  • Pruritus
  • Antinuclear antibody positivity
  • Psoriasiform dermatitis
  • Limitation of joint mobility
  • Abnormality of the wrist

Showing 5 of 29 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

12

Drugs / clinical candidates · MONDO_0019436

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

391

391 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

391 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

268 in the last 10 years · medium confidence · 73.1th percentile (publications denominator)

Phrase hits: 391 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,206

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Brunner HI14 papers · 2026

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

    Papers in Europe PMC
  2. 02
    Ruperto N11 papers · 2026

    Università degli Studi di Milano-Bicocca, Milan, Italy.

    Papers in Europe PMC
  3. 03
    Weiss PF10 papers · 2026

    Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

    Papers in Europe PMC
  4. 04
    Aalto K8 papers · 2025

    Department of Pediatrics, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.

    Papers in Europe PMC
  5. 05
    Berntson L8 papers · 2026

    Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. lillemor.berntson@telia.com.

    Papers in Europe PMC
  6. 06
    Lovell DJ7 papers · 2026

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

    Papers in Europe PMC
  7. 07
    Ramanan AV6 papers · 2026

    Bristol Royal Hospital for Children & Translational Health Sciences, University of Bristol, Bristol, United Kingdom.

    Papers in Europe PMC
  8. 08
    Brandon TG5 papers · 2024

    Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

    Papers in Europe PMC
  9. 09
    Ciurtin C5 papers · 2026

    Centre for Adolescent Rheumatology, Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, UK.

    Papers in Europe PMC
  10. 10
    Fasth A5 papers · 2025

    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

12

interventional trials for this specific condition

12 interventional trials matched this specific condition name; 6 currently recruiting in our sample. 173 trials are registered for juvenile idiopathic arthritis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

12 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.2th percentile).

medium confidence · 93.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

12 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: juvenile idiopathic arthritis

173

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 23 · after dedupe 22 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 22 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (22)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Psoriasis-related juvenile idiopathic arthritis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Psoriasis-related juvenile idiopathic arthritis" OR "Juvenile psoriatic arthritis" OR "Psoriasis-related JIA"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Psoriasis-related juvenile idiopathic arthritis" OR "Juvenile psoriatic arthritis" OR "Psoriasis-related JIA"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 12 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"juvenile idiopathic arthritis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: JPsA

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T03:01:55.359Z