ORPHA:842
Testicular seminomatous germ cell tumor
Also known as: Seminoma of testis · Seminomatous germ cell tumor of testis · Testicular seminoma
Publications
2,920
Trials
7
Interventional, condition-specific
Researchers
1,194
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Testicular seminomatous germ cell tumor is a rare testicular germ cell tumor, most commonly presenting with a painless mass in the scrotum, with a very high cure rate if caught in the early stages.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0003669
- UMLS:C5551428
- NCIT:C7328
Additional Mondo synonyms (10)
seminoma of testis · seminoma of the testis · seminomatous germ cell tumor of testis · seminomatous germ cell tumour of testis · testicular seminoma · testicular seminoma (disease) · testicular seminoma Pure · testicular seminomatous germ cell tumor · testicular seminomatous germ cell tumour · testis seminoma
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
2,920 matched papers (1,114 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
7 matched on ClinicalTrials.gov (5 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
2,920
2,920 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
2,920 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,114 in the last 10 years · low confidence
Phrase hits: 2,920 · MeSH hits: 0
Who's working on it?
1,194
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Zhang Y7 papers · 2026
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Papers in Europe PMC - 02Lauritsen J4 papers · 2025
Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Papers in Europe PMC - 03Lawrentschuk N4 papers · 2025
Department of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Papers in Europe PMC - 04Agerbæk M3 papers · 2025
Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Papers in Europe PMC - 05Bagrodia A3 papers · 2026
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX.
Papers in Europe PMC - 06Bernreuther C3 papers · 2026
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Papers in Europe PMC - 07Brand T3 papers · 2026
Department of Urology, Madigan Army Medical Center, Tacoma, WA.
Papers in Europe PMC - 08Burandt E3 papers · 2026
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Papers in Europe PMC - 09Cary C3 papers · 2025
Department of Urology, Indiana University School of Medicine, 340 W 10th St, 46202, Indianapolis, IN, USA.
Papers in Europe PMC - 10Chirico V3 papers · 2026
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
7
interventional trials for this specific condition
7 interventional trials matched this specific condition name; 5 currently recruiting in our sample.
Data as of 27 July 2026
7 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 89.9th percentile).
low confidence · 89.9th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
7 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06932458·RECRUITING·A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Conditions: Testicular Cancer·Matched via name phrase
- NCT07218913·RECRUITING·Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors
Conditions: Hearing Loss · Metastatic Malignant Germ Cell Tumor · Metastatic Malignant Nongerminomatous Germ Cell Tumor · Metastatic Malignant Testicular Non-Seminomatous Germ Cell Tumor·Matched via name phrase
- NCT05345158·RECRUITING·R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma
Conditions: Lymphadenopathy Retroperitoneal · Stage II Testicular Seminoma·Matched via name phrase
- NCT03067181·RECRUITING·Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Conditions: Childhood Extracranial Germ Cell Tumor · Extragonadal Embryonal Carcinoma · Germ Cell Tumor · Malignant Germ Cell Tumor·Matched via name phrase
- NCT05500391·RECRUITING·Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring
Conditions: Stage I Testicular Seminoma · Stage I Testicular Nonseminomatous Germ Cell Tumor · Gastrointestinal Stromal Tumors · Ovarian Germ Cell Tumor·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Testicular seminomatous germ cell tumor" OR "Seminoma of testis" OR "Seminoma of the testis" OR "Seminomatous germ cell tumor of testis" OR "Seminomatous germ cell tumor of the testis" OR "Testicular seminoma" OR "seminomatous germ cell tumour of testis" OR "seminomatous germ cell tumour of the testis" OR "testicular seminoma (disease)" OR "testicular seminoma Pure" OR "testicular seminomatous germ cell tumour" OR "testis seminoma"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Testicular seminomatous germ cell tumor" OR "Seminoma of testis" OR "Seminoma of the testis" OR "Seminomatous germ cell tumor of testis" OR "Seminomatous germ cell tumor of the testis" OR "Testicular seminoma" OR "seminomatous germ cell tumour of testis" OR "seminomatous germ cell tumour of the testis" OR "testicular seminoma (disease)" OR "testicular seminoma Pure" OR "testicular seminomatous germ cell tumour" OR "testis seminoma"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 7 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (2920) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T15:37:15.549Z