ORPHA:83601
Steroid-responsive encephalopathy associated with autoimmune thyroiditis
Also known as: Hashimoto encephalitis · SREAT
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
685
Trials
0
Interventional, condition-specific
Researchers
1,077
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Steroid-responsive associated with autoimmune thyroiditis (SREAT) is a rare, acquired, neurological disease characterized by associated with elevated antithyroid antibodies, in the absence of other causes. Clinical presentation varies from minor cognitive impairment to status epilepticus and coma, and frequently includes , confusion, speech disorder, memory impairment, and psychiatric manifestations.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019385
- MeSH:C535841
- UMLS:C0393639
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
685 matched papers (295 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
685
685 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
685 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
295 in the last 10 years · low confidence
Phrase hits: 685 · MeSH hits: 0
Who's working on it?
1,077
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Endres D8 papers · 2023
Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstr. 5, 79104, Freiburg, Germany. dominique.endres@uniklinik-freiburg.de.
Papers in Europe PMC - 02Tebartz van Elst L7 papers · 2023
Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstr. 5, 79104, Freiburg, Germany. tebartzvanelst@uniklinik-freiburg.de.
Papers in Europe PMC - 03Stich O6 papers · 2020
Department of Neurology, University Medical Center Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany. oliver.stich@uniklinik-freiburg.de.
Papers in Europe PMC - 04Dersch R4 papers · 2022
Department for Neurology, University Medical Center Freiburg Freiburg, Germany.
Papers in Europe PMC - 05Domschke K4 papers · 2023
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Papers in Europe PMC - 06Perlov E4 papers · 2017
Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstr. 5, 79104, Freiburg, Germany. evgeniy.perlov@uniklinik-freiburg.de.
Papers in Europe PMC - 07Bernad PG3 papers · 2025
Neurology, George Washington University Hospital, Washington, DC, USA.
Papers in Europe PMC - 08Flanagan EP3 papers · 2023
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Papers in Europe PMC - 09Nickel K3 papers · 2023
Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Papers in Europe PMC - 10Pollak TA3 papers · 2025
Neuropsychiatry Research and Education Group, King's College London, London, UK.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT05017142·RECRUITING·Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
Conditions: Optic Neuritis · Transverse Myelitis · Acute Disseminated Encephalomyelitis · Multiple Sclerosis·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Steroid-responsive encephalopathy associated with autoimmune thyroiditis" OR "Hashimoto encephalitis" OR "SREAT"
MeSH descriptor terms unioned into the query: Hashimoto's encephalitis
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Steroid-responsive encephalopathy associated with autoimmune thyroiditis" OR "Hashimoto encephalitis" OR "SREAT" OR "Hashimoto's encephalitis"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (685) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-27T02:40:36.753Z