ORPHA:83595
Colorado tick fever
Also known as: American mountain fever · Colorado tick encephalitis · Colorado tick-borne disease · Mountain fever · Mountain tick fever
Publications
1,058
Trials
0
Interventional, condition-specific
Researchers
1,096
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
An acute arboviral infection caused by a Coltivirus transmitted by an infected tick and characterized by a biphasic fever with headache, myalgias, arthralgias, and fatigue that can last 3 weeks or more. In some cases, macular, maculopapular, or petechial rash and/or stiff neck, nausea, vomiting, abdominal pain, diarrhea, and sore throat may also occur.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0005708
- MeSH:D003121
- UMLS:C0009400
Additional Mondo synonyms (3)
Colorado tick fever virus caused disease or disorder · Colorado tick fever virus disease or disorder · Colorado tick fever virus infectious disease
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,058 matched papers (293 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,058
1,058 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,058 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
293 in the last 10 years · low confidence
Phrase hits: 1,058 · MeSH hits: 21
Who's working on it?
1,096
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Holmes EC7 papers · 2025
Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Papers in Europe PMC - 02Eisen RJ6 papers · 2024
Rebecca J. Eisen, PhD, is a Research Biologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Kiersten J. Kugeler, PhD, is an Epidemiologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Lars Eisen, PhD, is a Research Entomologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Charles B. Beard, PhD, is a Branch Chief in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Christopher D. Paddock, MD, is a Medical Officer/Pathologist in the Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Atlanta, Georgia.
Papers in Europe PMC - 03Staples JE6 papers · 2023
Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 04Eisen L5 papers · 2026
Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA. Electronic address: evp4@cdc.gov.
Papers in Europe PMC - 05Fischer M4 papers · 2020
Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 06Harvey E4 papers · 2021
Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Papers in Europe PMC - 07Li Y4 papers · 2024
Centers for Disease Control and Prevention, NCIRD, DVD, Atlanta, Georgia 30329, USA.
Papers in Europe PMC - 08Shimada T4 papers · 2022
National Institute of Infectious Diseases, Tokyo, Japan.
Papers in Europe PMC - 09Bamunuarachchi G3 papers · 2025
Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Papers in Europe PMC - 10Bechelli J3 papers · 2025
Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77340, USA. Electronic address: jrb138@shsu.edu.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Colorado tick fever" OR "American mountain fever" OR "Colorado tick encephalitis" OR "Colorado tick-borne disease" OR "Mountain fever" OR "Mountain tick fever" OR "Colorado tick fever virus infectious disease"
MeSH descriptor terms unioned into the query: Colorado Tick Fever
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Colorado tick fever" OR "American mountain fever" OR "Colorado tick encephalitis" OR "Colorado tick-borne disease" OR "Mountain fever" OR "Mountain tick fever" OR "Colorado tick fever virus infectious disease"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: Colorado tick fever virus caused disease or disorder; Colorado tick fever virus disease or disorder
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (1058) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T02:39:55.139Z