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ORPHA:83595

Colorado tick fever

low confidenceDisorder

Also known as: American mountain fever · Colorado tick encephalitis · Colorado tick-borne disease · Mountain fever · Mountain tick fever

Publications

1,058

Trials

0

Interventional, condition-specific

Researchers

1,096

Distinct authors in sample

Gene link

—

Readiness

1/6

Stages with a signal

Clinical definition (Orphanet)

An acute arboviral infection caused by a Coltivirus transmitted by an infected tick and characterized by a biphasic fever with headache, myalgias, arthralgias, and fatigue that can last 3 weeks or more. In some cases, macular, maculopapular, or petechial rash and/or stiff neck, nausea, vomiting, abdominal pain, diarrhea, and sore throat may also occur.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

Colorado tick fever virus caused disease or disorder · Colorado tick fever virus disease or disorder · Colorado tick fever virus infectious disease

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

1/6 stages with a signal

Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,058 matched papers (293 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialNot found

    No matched interventional trial under our ClinicalTrials.gov rules

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,058

1,058 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,058 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

293 in the last 10 years · low confidence

Phrase hits: 1,058 · MeSH hits: 21

Open Europe PMC search

Who's working on it?

1,096

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Holmes EC7 papers · 2025

    Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.

    Papers in Europe PMC
  2. 02
    Eisen RJ6 papers · 2024

    Rebecca J. Eisen, PhD, is a Research Biologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Kiersten J. Kugeler, PhD, is an Epidemiologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Lars Eisen, PhD, is a Research Entomologist in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Charles B. Beard, PhD, is a Branch Chief in the Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Fort Collins, Colorado. Christopher D. Paddock, MD, is a Medical Officer/Pathologist in the Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention in Atlanta, Georgia.

    Papers in Europe PMC
  3. 03
    Staples JE6 papers · 2023

    Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.

    Papers in Europe PMC
  4. 04
    Eisen L5 papers · 2026

    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA. Electronic address: evp4@cdc.gov.

    Papers in Europe PMC
  5. 05
    Fischer M4 papers · 2020

    Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.

    Papers in Europe PMC
  6. 06
    Harvey E4 papers · 2021

    Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.

    Papers in Europe PMC
  7. 07
    Li Y4 papers · 2024

    Centers for Disease Control and Prevention, NCIRD, DVD, Atlanta, Georgia 30329, USA.

    Papers in Europe PMC
  8. 08
    Shimada T4 papers · 2022

    National Institute of Infectious Diseases, Tokyo, Japan.

    Papers in Europe PMC
  9. 09
    Bamunuarachchi G3 papers · 2025

    Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

    Papers in Europe PMC
  10. 10
    Bechelli J3 papers · 2025

    Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77340, USA. Electronic address: jrb138@shsu.edu.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).

Data as of 11 September 2026 · last trial check 11 September 2026

No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.

low confidence · 38.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Colorado tick fever — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Colorado tick fever" OR "American mountain fever" OR "Colorado tick encephalitis" OR "Colorado tick-borne disease" OR "Mountain fever" OR "Mountain tick fever" OR "Colorado tick fever virus infectious disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Colorado Tick Fever

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Colorado tick fever" OR "American mountain fever" OR "Colorado tick encephalitis" OR "Colorado tick-borne disease" OR "Mountain fever" OR "Mountain tick fever" OR "Colorado tick fever virus infectious disease"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: Colorado tick fever virus caused disease or disorder; Colorado tick fever virus disease or disorder

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1058) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T02:39:55.139Z