ORPHA:83594
Eastern equine encephalitis
Also known as: Eastern equine encephalomyelitis
Publications
3,919
Trials
3
Interventional, condition-specific
Researchers
1,287
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
An acute arboviral infection caused by an alphavirus of the Togaviridae family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. , which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0005736
- MeSH:D020242
- UMLS:C0153065
Additional Mondo synonyms (1)
Neuroinvasive Eastern equine encephalitis virus infection
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
3,919 matched papers (1,718 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
3 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
3,919
3,919 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
3,919 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,718 in the last 10 years · low confidence
Phrase hits: 3,919 · MeSH hits: 2
Who's working on it?
1,287
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Staples JE8 papers · 2026
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 02Weaver SC8 papers · 2025
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Papers in Europe PMC - 03Gould CV7 papers · 2026
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 04Klimstra WB6 papers · 2026
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Klimstra@pitt.edu.
Papers in Europe PMC - 05Hamer GL5 papers · 2026
Department of Entomology, Texas A&M University, College Station, TX, USA.
Papers in Europe PMC - 06Bauer A4 papers · 2026
Florida Medical Entomology Laboratory (FMEL), Department of Entomology and Nematology, University of Florida Institute of Food and Agricultural Sciences (UF/IFAS), Gainesville, FL, USA.
Papers in Europe PMC - 07Burkett-Cadena ND4 papers · 2025
Florida Medical Entomology Laboratory, University of Florida IFAS, 200 9th Street SE, Vero Beach, FL 32962, USA.
Papers in Europe PMC - 08Diamond MS4 papers · 2026
Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Papers in Europe PMC - 09Guralnick R4 papers · 2026
Department of Natural Resources, University of Florida, Gainesville, FL, USA.
Papers in Europe PMC - 10Hanley KA4 papers · 2026
Department of Biology, New Mexico State University , Las Cruces, New Mexico, USA.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
3
interventional trials for this specific condition
3 interventional trials matched this specific condition name; none in our sample are currently recruiting.
Data as of 27 July 2026
3 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 85.1th percentile).
low confidence · 85.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
3 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Eastern equine encephalitis" OR "Eastern equine encephalomyelitis" OR "Neuroinvasive Eastern equine encephalitis virus infection"
MeSH descriptor terms unioned into the query: Encephalomyelitis, Eastern Equine
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Eastern equine encephalitis" OR "Eastern equine encephalomyelitis" OR "Neuroinvasive Eastern equine encephalitis virus infection" OR "Encephalomyelitis, Eastern Equine"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 3 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (3919) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T02:39:40.896Z