ORPHA:83484
St. Louis encephalitis
Also known as: Saint Louis encephalitis
Publications
5,047
Trials
0
Interventional, condition-specific
Researchers
1,412
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
An acute arboviral infection caused by a virus of the Flaviviridae family transmitted by an infected mosquito, and characterized by the onset of flu-like symptoms such as fever, malaise, headache, cough, and sore throat that can progress to meningitis or encephalitis with symptoms like nausea, vomiting, confusion, stiff neck, disorientation, irritability, tremors, and convulsions. Photophobia, cranial nerve palsies, and even coma may occur.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0005969
- MeSH:D004674
- UMLS:C0014060
Additional Mondo synonyms (3)
Neuroinvasive St. Louis encephalitis virus infection · St. Louis encephalitis virus caused infectious encephalitis · St. Louis encephalitis virus infectious encephalitis
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
5,047 matched papers (1,904 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
5,047
5,047 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
5,047 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,904 in the last 10 years · low confidence
Phrase hits: 5,046 · MeSH hits: 14
Who's working on it?
1,412
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Diaz A10 papers · 2026
Instituto de Virología, "Dr J.M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Papers in Europe PMC - 02Staples JE5 papers · 2026
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 03Gould CV4 papers · 2026
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Papers in Europe PMC - 04Townsend J4 papers · 2026
Vector Control Division, Maricopa County Environmental Services Department, Phoenix, AZ, United States.
Papers in Europe PMC - 05Almirón WR3 papers · 2025
Universidad Nacional de Córdoba, Centro de Investigaciones Entomológicas de Córdoba,Facultad de Ciencias Exactas, Físicas y Naturales, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biológicas y Tecnológicas, Córdoba, Argentina.
Papers in Europe PMC - 06Bajay MM3 papers · 2026
State University of Santa Catarina (UDESC) - Center for Agricultural and Veterinary Sciences, Santa Catarina, Brazil.
Papers in Europe PMC - 07de Lima Neto DF3 papers · 2026
Laboratory of Molecular Evolution and Bioinformatics, Center for Biological Sciences, Department of Microbiology, University of São Paulo, São Paulo, Brazil.
Papers in Europe PMC - 08Duggal NK3 papers · 2025
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States. Electronic address: nduggal@vt.edu.
Papers in Europe PMC - 09Laurito M3 papers · 2026
Departamento de Ciencias Básicas y Tecnológicas, Universidad Nacional de Chilecito, Chilecito, La Rioja 5360, Argentina; Consejo Nacional de Investigación Científica y Técnica (CONICET), Argentina.
Papers in Europe PMC - 10Lyons S3 papers · 2025Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"St. Louis encephalitis" OR "Saint Louis encephalitis" OR "Neuroinvasive St. Louis encephalitis virus infection" OR "St. Louis encephalitis virus caused infectious encephalitis" OR "St. Louis encephalitis virus infectious encephalitis"
MeSH descriptor terms unioned into the query: Encephalitis, St. Louis
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"St. Louis encephalitis" OR "Saint Louis encephalitis" OR "Neuroinvasive St. Louis encephalitis virus infection" OR "St. Louis encephalitis virus caused infectious encephalitis" OR "St. Louis encephalitis virus infectious encephalitis" OR "Encephalitis, St. Louis"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (5047) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T02:39:11.010Z