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ORPHA:83468

Solitary bone cyst

low confidenceDisorder

Also known as: Juvenile bone cyst

Publications

12,292

Trials

15

Interventional, condition-specific

Researchers

946

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cases involving the jaw bone have been reported.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

bone cyst · cyst of bone · cyst of the bone · simple bone cyst · solitary cyst · unicameral bone cyst

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    12,292 matched papers (5,745 in last 10 years) Source

  3. Phenotype characterisedPresent

    17 HPO annotations (e.g. Abnormal humeral diaphysis morphology; Abnormality of the medullary cavity of the long bones; Prominent calcaneus) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    15 matched on ClinicalTrials.gov (3 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

17

Associated phenotypes · MONDO:0019372

  • Abnormal humeral diaphysis morphology
  • Abnormality of the medullary cavity of the long bones
  • Prominent calcaneus
  • Abnormality of the nervous system
  • Abnormal spinal cord morphology

Showing 5 of 17 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

12,292

12,292 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

12,292 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

5,745 in the last 10 years · low confidence

Phrase hits: 12,213 · MeSH hits: 287

Open Europe PMC search

Who's working on it?

946

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li H3 papers · 2025

    Third Affiliated Hospital, Southern Medical University, Guangzhou, China.

    Papers in Europe PMC
  2. 02
    Liu Y3 papers · 2026

    Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.

    Papers in Europe PMC
  3. 03
    Rajeswaran S3 papers · 2026

    Division of Interventional Radiology, Department of Radiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

    Papers in Europe PMC
  4. 04
    Wang J3 papers · 2026

    Department of Orthopaedics, The Third People's Hospital of Cangnan County, Wenzhou, China.

    Papers in Europe PMC
  5. 05
    Abd Rasid AF2 papers · 2024

    Department of Orthopaedics and Traumatology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

    Papers in Europe PMC
  6. 06
    Angelini A2 papers · 2024

    Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy.

    Papers in Europe PMC
  7. 07
    Arkader A2 papers · 2025

    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

    Papers in Europe PMC
  8. 08
    Bara Z2 papers · 2026

    Clinic of Pediatric Surgery and Orthopedics, County Emergency Clinical Hospital Târgu Mures, 50 Gh. Marinescu Street, 540136 Târgu Mureș, Romania.

    Papers in Europe PMC
  9. 09
    Botchu R2 papers · 2025

    Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK.

    Papers in Europe PMC
  10. 10
    Chai W2 papers · 2021

    Department of Orthopaedics, Chinese PLA General Hospital, Beijing, 100853, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

15

interventional trials for this specific condition

15 interventional trials matched this specific condition name; 3 currently recruiting in our sample.

Data as of 11 September 2026

15 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 94th percentile).

low confidence · 94th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

15 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

5 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 7 · after dedupe 7 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 7 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (7)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Solitary bone cyst — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Solitary bone cyst" OR "Juvenile bone cyst" OR "bone cyst" OR "cyst of bone" OR "cyst of the bone" OR "simple bone cyst" OR "solitary cyst" OR "unicameral bone cyst"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Bone Cysts

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Solitary bone cyst" OR "Juvenile bone cyst" OR "bone cyst" OR "cyst of bone" OR "cyst of the bone" OR "simple bone cyst" OR "solitary cyst" OR "unicameral bone cyst" OR "Bone Cysts"

Interventional trials matched via: both, phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 15 interventional · 5 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (12292) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T02:37:23.516Z