ORPHA:83468
Solitary bone cyst
Also known as: Juvenile bone cyst
Publications
12,292
Trials
15
Interventional, condition-specific
Researchers
946
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A benign non-epithelial bone cavity that is asymptomatic and that is found most commonly in the second decade of life by chance. The long bones are most often affected, but cases involving the jaw bone have been reported.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019372
- MeSH:D001845
- UMLS:C0005937
- NCIT:C2904
Additional Mondo synonyms (6)
bone cyst · cyst of bone · cyst of the bone · simple bone cyst · solitary cyst · unicameral bone cyst
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
12,292 matched papers (5,745 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
15 matched on ClinicalTrials.gov (3 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
12,292
12,292 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
12,292 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
5,745 in the last 10 years · low confidence
Phrase hits: 12,213 · MeSH hits: 287
Who's working on it?
946
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Li H3 papers · 2025
Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Papers in Europe PMC - 02Liu Y3 papers · 2026
Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Papers in Europe PMC - 03Rajeswaran S3 papers · 2026
Division of Interventional Radiology, Department of Radiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Papers in Europe PMC - 04Wang J3 papers · 2026
Department of Orthopaedics, The Third People's Hospital of Cangnan County, Wenzhou, China.
Papers in Europe PMC - 05Abd Rasid AF2 papers · 2024
Department of Orthopaedics and Traumatology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.
Papers in Europe PMC - 06Angelini A2 papers · 2024
Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy.
Papers in Europe PMC - 07Arkader A2 papers · 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Papers in Europe PMC - 08Bara Z2 papers · 2026
Clinic of Pediatric Surgery and Orthopedics, County Emergency Clinical Hospital Târgu Mures, 50 Gh. Marinescu Street, 540136 Târgu Mureș, Romania.
Papers in Europe PMC - 09Botchu R2 papers · 2025
Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK.
Papers in Europe PMC - 10Chai W2 papers · 2021
Department of Orthopaedics, Chinese PLA General Hospital, Beijing, 100853, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
15
interventional trials for this specific condition
15 interventional trials matched this specific condition name; 3 currently recruiting in our sample.
Data as of 27 July 2026
15 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 93.5th percentile).
low confidence · 93.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
15 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06567535·RECRUITING·Treatment of Mandibular Bone Cyst by Navigation and Endoscopy
Conditions: Jaw Cysts·Matched via name phrase
- NCT07066228·RECRUITING·Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Long Tubular Bone Defects
Conditions: Defective Composite Restorations · Bone Cysts · Bone Defect · Bone Nonunion·Matched via MeSH
- NCT02193841·RECRUITING·Simple Bone Cysts in Kids
Conditions: Bone Cyst·Matched via name + MeSH
Observational and natural-history studies
5 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Solitary bone cyst" OR "Juvenile bone cyst" OR "bone cyst" OR "cyst of bone" OR "cyst of the bone" OR "simple bone cyst" OR "solitary cyst" OR "unicameral bone cyst"
MeSH descriptor terms unioned into the query: Bone Cysts
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Solitary bone cyst" OR "Juvenile bone cyst" OR "bone cyst" OR "cyst of bone" OR "cyst of the bone" OR "simple bone cyst" OR "solitary cyst" OR "unicameral bone cyst" OR "Bone Cysts"
Interventional trials matched via: both, phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 15 interventional · 5 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (12292) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T02:37:23.516Z