ORPHA:83317
Scrub typhus
Also known as: Tsutsugamushi disease · Tsutsugamushi fever
Publications
8,820
Trials
4
Interventional, condition-specific
Researchers
1,103
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Scrub typhus is a rare dust mite-borne infectious disease caused by the Orientia tsutsugamushi bacterium and characterized clinically by an eruptive fever which is potentially serious.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019365
- MeSH:D012612
- UMLS:C0036472
Additional Mondo synonyms (6)
Japanese river fever · Kedani fever · scrub mite-borne typhus · tsutsugamushi · tsutsugamushi disease · tsutsugamushi fever
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
8,820 matched papers (4,624 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
4 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
8,820
8,820 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
8,820 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
4,624 in the last 10 years · low confidence
Phrase hits: 8,820 · MeSH hits: 141
Who's working on it?
1,103
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Zhang L8 papers · 2026
Department of Infectious Diseases, The Second Affiliated Hospital, Hainan Medical University, Haikou 570311, China.
Papers in Europe PMC - 02Wang Y7 papers · 2026
Second Department of Infectious Disease, Kunming Children's Hospital (Children's Hospital Affiliated to Kunming Medical University), Kunming, Yunnan, China.
Papers in Europe PMC - 03Yin F7 papers · 2026
The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases-Hainan Medical University, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, China.
Papers in Europe PMC - 04Zhang Y7 papers · 2026
Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, China.
Papers in Europe PMC - 05Chen S6 papers · 2026
The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases-Hainan Medical University, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, China.
Papers in Europe PMC - 06Chen Y6 papers · 2026
Department of Infectious Diseases, The Second Affiliated Hospital, Hainan Medical University, Haikou 570311, China.
Papers in Europe PMC - 07Guo Y6 papers · 2026
The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases-Hainan Medical University, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, China.
Papers in Europe PMC - 08Day NPJ5 papers · 2026
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Papers in Europe PMC - 09
- 10Liang Y5 papers · 2026
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
4
interventional trials for this specific condition
4 interventional trials matched this specific condition name; none in our sample are currently recruiting.
Data as of 27 July 2026
4 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 86.7th percentile).
low confidence · 86.7th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
4 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Broader category: typhus
0
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Parent-category matching found a broader label but no interventional trials under it. How we count trials.
Observational and natural-history studies
7 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Scrub typhus" OR "Tsutsugamushi disease" OR "Tsutsugamushi fever" OR "Japanese river fever" OR "Kedani fever" OR "scrub mite-borne typhus" OR "tsutsugamushi"
MeSH descriptor terms unioned into the query: Scrub Typhus
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Scrub typhus" OR "Tsutsugamushi disease" OR "Tsutsugamushi fever" OR "Japanese river fever" OR "Kedani fever" OR "scrub mite-borne typhus" OR "tsutsugamushi"
Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 4 interventional · 7 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"typhus"
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (8820) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T02:34:17.412Z