RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:79124

Hepatic veno-occlusive disease-immunodeficiency syndrome

low confidenceDisorder

Also known as: VODI syndrome

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

1,817

Trials

0

Interventional, condition-specific

Researchers

10

Distinct authors in sample

Gene link

SP110

Definitive

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare syndrome with combined immunodeficiency characterized by the association of severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, absent tissue plasma cells and hepatic veno-occlusive disease.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedPresent

    Definitive — SP110

  2. LiteraturePresent

    1,817 matched papers (1,235 in last 10 years) Source

  3. Phenotype characterisedPresent

    45 HPO annotations (e.g. Abnormal circulating interleukin concentration; Cough; Recurrent gastroenteritis) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPartial

    None under the specific name; 7 for broader category hepatic veno-occlusive disease

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Yes — we know a specific gene responsible (SP110).

GenCC classification: Definitive.

Phenotypes (Monarch / HPO)

45

Associated phenotypes · MONDO:0009338

  • Abnormal circulating interleukin concentration
  • Cough
  • Recurrent gastroenteritis
  • Ascites
  • Pancytopenia

Showing 5 of 45 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,817

1,817 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,817 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,235 in the last 10 years · low confidence

Phrase hits: 2 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

10

Distinct author names in 2 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Abolhassani H1 paper · 2023

    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  2. 02
    Ayati A1 paper · 2023

    Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Science, Tehran, Iran.

    Papers in Europe PMC
  3. 03
    Ebadi M1 paper · 2024

    Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

    Papers in Europe PMC
  4. 04
    Ghoraeian P1 paper · 2024

    Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

    Papers in Europe PMC
  5. 05
    Mardani M1 paper · 2023

    School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  6. 06
    Mohammadi F1 paper · 2023

    School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  7. 07
    Mohammadi P1 paper · 2024

    Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

    Papers in Europe PMC
  8. 08
    Noruzinia M1 paper · 2024

    Department of Medical Genetics, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran. Email: Noruzinia@modares.ac.ir.

    Papers in Europe PMC
  9. 09
    Rezaei N1 paper · 2023

    Universal Scientific Education and Research Network (USERN), Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Tehran, Iran.

    Papers in Europe PMC
  10. 10
    Yadegar A1 paper · 2023

    School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 7 trials are registered for hepatic veno-occlusive disease, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026 · last trial check 11 September 2026

No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.

low confidence · 38.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

7 interventional trials matched hepatic veno-occlusive disease, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: hepatic veno-occlusive disease

7

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Hepatic veno-occlusive disease-immunodeficiency syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Hepatic veno-occlusive disease-immunodeficiency syndrome" OR "VODI syndrome") OR (MESH:"Hepatic venoocclusive disease with immunodeficiency") OR ("SP110" OR "SP110 syndrome" OR "SP110-related")

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Hepatic venoocclusive disease with immunodeficiency

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Hepatic veno-occlusive disease-immunodeficiency syndrome" OR "VODI syndrome" OR "Hepatic venoocclusive disease with immunodeficiency"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"hepatic veno-occlusive disease"

Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1817) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T01:58:20.005Z