ORPHA:79102
Thyrotoxic periodic paralysis
Also known as: Thyrotoxic hypokalemic periodic paralysis
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
1,074
90th percentile
Trials
0
Interventional, condition-specific
Researchers
801
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A form of acquired hypokalemic periodic paralysis characterized by a triad of acute flaccid paralysis, hypokalemia, and thyrotoxicosis. These episodes vary in duration, lasting from 2 to 72 hours, and in severity, ranging from paresis to complete paralysis. Attacks are triggered by carbohydrate-rich meals or by strenuous physical activity, followed by a period of rest.
How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019201
- UMLS:C0268446
Additional Mondo synonyms (1)
thyrotoxic hypokalemic periodic paralysis
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,074 matched papers (487 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 5 for broader category periodic paralysis
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,074
1,074 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,074 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
487 in the last 10 years · high confidence · 90th percentile (publications denominator)
Phrase hits: 1,074 · MeSH hits: 0
Who's working on it?
801
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Baral S3 papers · 2025
Department of Internal Medicine Rapti Academy of Health Sciences Dang Nepal.
Papers in Europe PMC - 02Lin SH3 papers · 2024
Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
Papers in Europe PMC - 03Bashir AM2 papers · 2023
Department of Internal Medicine, Mogadishu Somali Turkey Training and Research Hospital, Mogadishu, Somalia. ambashir@hotmail.com.
Papers in Europe PMC - 04Bhattarai S2 papers · 2025
Department of Internal Medicine Rapti Academy of Health Sciences Dang Nepal.
Papers in Europe PMC - 05Effraimidis G2 papers · 2026
Department of Endocrinology and Metabolic Diseases, Larissa University Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Papers in Europe PMC - 06Ganiyeva I2 papers · 2026
Pediatric Diseases Department, Astana Medical University, Astana 010000, Kazakhstan.
Papers in Europe PMC - 07Ghedi AKA2 papers · 2023
Department of Internal Medicine, Mogadishu Somali Turkey Training and Research Hospital, Mogadishu, Somalia.
Papers in Europe PMC - 08Jeele MOO2 papers · 2023
Department of Internal Medicine, Mogadishu Somali Turkey Training and Research Hospital, Mogadishu, Somalia.
Papers in Europe PMC - 09Khan A2 papers · 2023
Department of Internal Medicine Hamad General Hospital Hamad Medical Corporation Doha Qatar.
Papers in Europe PMC - 10Khan M2 papers · 2024
Department of Endocrinology, Diabetes and Metabolism, SUNY (State University of New York) Downstate Health Science University, New York, USA.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 2 observational studies did — shown below because natural-history and cohort work can be an important step toward a trial. 5 trials are registered for periodic paralysis, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
5 interventional trials matched periodic paralysis, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: periodic paralysis
5
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07194174·RECRUITING·Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis
Conditions: Hypokalemic Periodic Paralysis · Hyperkalemic Periodic Paralysis·Matched via name phrase
Observational and natural-history studies
2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Thyrotoxic periodic paralysis" OR "Thyrotoxic hypokalemic periodic paralysis"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Thyrotoxic periodic paralysis" OR "Thyrotoxic hypokalemic periodic paralysis" OR "familial periodic paralysis"
Recall-expansion terms: familial periodic paralysis
Study-type breakdown: 0 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"periodic paralysis"
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T01:57:11.874Z