RARE DISEASERESEARCH ATLAS
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ORPHA:770

Rabies

medium confidenceDisorder

Publications

54,039

98.8th percentile

Trials

103

Interventional, condition-specific

Researchers

1,317

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Rabies is a viral zoonosis leading to a fatal if not treated.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

lyssa

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    54,039 matched papers (22,722 in last 10 years) Source

  3. Phenotype characterisedPresent

    23 HPO annotations (e.g. Fever; Migraine; Reduced consciousness) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    103 matched on ClinicalTrials.gov (13 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

23

Associated phenotypes · MONDO:0019173

  • Fever
  • Migraine
  • Reduced consciousness
  • Cerebral palsy
  • Vocal cord paresis

Showing 5 of 23 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

1 associated chemical. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • cinnabarin · therapeutic

MyDisease.info · MONDO:0019173

Literature

Is anyone studying this?

54,039

54,039 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

54,039 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

22,722 in the last 10 years · medium confidence · 98.8th percentile (publications denominator)

Phrase hits: 54,039 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,317

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hampson K6 papers · 2026

    School of Biodiversity, One Health & Veterinary Medicine, , ,

    Papers in Europe PMC
  2. 02
    Gupta S5 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  3. 03
    Mani RS5 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address: drreeta@gmail.com.

    Papers in Europe PMC
  4. 04
    Müller T5 papers · 2026

    Institute of Molecular Virology and Cell Biology (WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies), Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems ,

    Papers in Europe PMC
  5. 05
    Rupprecht CE5 papers · 2026

    College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

    Papers in Europe PMC
  6. 06
    Ashwini MA4 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  7. 07
    Liu X4 papers · 2026

    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

    Papers in Europe PMC
  8. 08
    Lodha L4 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  9. 09
    Ma Y4 papers · 2026

    The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.

    Papers in Europe PMC
  10. 10
    Wallace RM4 papers · 2026

    Poxvirus and Rabies Branch, US Centers for Disease Control and Prevention, Atlanta, GeorgiaUnited States of America.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

103

interventional trials for this specific condition

103 interventional trials matched this specific condition name; 13 currently recruiting in our sample.

Data as of 11 September 2026

103 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 98.6th percentile).

medium confidence · 98.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

103 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 23 · after dedupe 22 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 22 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (22)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Rabies — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Rabies" OR "lyssa"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Rabies" OR "lyssa"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 103 interventional · 8 observational · 1 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T15:17:45.895Z