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ORPHA:770

Rabies

medium confidenceDisorder

Publications

54,039

99.4th percentile

Trials

103

Interventional, condition-specific

Researchers

1,317

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Rabies is a viral zoonosis leading to a fatal if not treated.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

lyssa

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    54,039 matched papers (22,722 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    103 matched on ClinicalTrials.gov (13 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

54,039

54,039 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

54,039 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

22,722 in the last 10 years · medium confidence · 99.4th percentile (publications denominator)

Phrase hits: 54,039 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,317

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hampson K6 papers · 2026

    School of Biodiversity, One Health & Veterinary Medicine, , ,

    Papers in Europe PMC
  2. 02
    Gupta S5 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  3. 03
    Mani RS5 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address: drreeta@gmail.com.

    Papers in Europe PMC
  4. 04
    Müller T5 papers · 2026

    Institute of Molecular Virology and Cell Biology (WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies), Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems ,

    Papers in Europe PMC
  5. 05
    Rupprecht CE5 papers · 2026

    College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

    Papers in Europe PMC
  6. 06
    Ashwini MA4 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  7. 07
    Liu X4 papers · 2026

    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

    Papers in Europe PMC
  8. 08
    Lodha L4 papers · 2026

    Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.

    Papers in Europe PMC
  9. 09
    Ma Y4 papers · 2026

    The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.

    Papers in Europe PMC
  10. 10
    Wallace RM4 papers · 2026

    Poxvirus and Rabies Branch, US Centers for Disease Control and Prevention, Atlanta, GeorgiaUnited States of America.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

103

interventional trials for this specific condition

103 interventional trials matched this specific condition name; 13 currently recruiting in our sample.

Data as of 27 July 2026

103 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 98.5th percentile).

medium confidence · 98.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

103 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Rabies" OR "lyssa"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Rabies" OR "lyssa"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 103 interventional · 8 observational · 1 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T15:17:45.895Z