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ORPHA:73263

Zygomycosis

low confidenceDisorder

Also known as: Mucormycosis

Publications

15,925

Trials

14

Interventional, condition-specific

Researchers

1,165

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare mycosis caused by ubiquitous, opportunistic fungi of the order Mucorales, characterized by tissue infarction and necrosis due to invasion of the vasculature by hyphae. The spectrum of clinical manifestations depends on the route of infection and includes rhinocerebral, pulmonary, cutaneous, gastrointestinal, renal, and disseminated forms. The disease is usually rapidly and associated with high mortality.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

Zygomycota infectious disease · mucormycosis

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    15,925 matched papers (9,439 in last 10 years) Source

  3. Phenotype characterisedPresent

    76 HPO annotations (e.g. Sinusitis; Fever; Pain) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    3 FDA · 2 EMA designations (2 FDA orphan-indication approvals) — e.g. posaconazole Source

  6. Interventional trialPresent

    14 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

76

Associated phenotypes · MONDO:0019136

  • Sinusitis
  • Fever
  • Pain
  • Cough
  • Unusual skin infection

Showing 5 of 76 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

5

Designations · 2 with FDA orphan-indication approval

  • FDA posaconazoleZygomycosis · 2004-07-16 · Not FDA Approved for Orphan Indication
  • FDA Amphotericin B lipid complexZygomycosis · 1996-05-06 · Not FDA Approved for Orphan Indication
  • EMA FosmanogepixTreatment of mucormycosis · 15/02/2023 · PositiveEMA designation
  • EMA Isavuconazonium sulfate (Cresemba)Treatment of mucormycosis · 04/06/2014 · PositiveEMA designation
  • FDA isavuconazonium sulfate (Cresemba)Zygomycosis · 2013-10-25

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

5

Drugs / clinical candidates · MONDO_0019136

CTD chemicals (MyDisease.info)

2 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Amphotericin B · therapeutic
  • Trimethoprim, Sulfamethoxazole Drug Combination · therapeutic

MyDisease.info · MONDO:0019136

Literature

Is anyone studying this?

15,925

15,925 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

15,925 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

9,439 in the last 10 years · low confidence

Phrase hits: 15,925 · MeSH hits: 85

Open Europe PMC search

Who's working on it?

1,165

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Chakrabarti A5 papers · 2026

    Doodhadhari Burfani Hospital, Bhupatwala, Haridwar, Uttarakhand, India.

    Papers in Europe PMC
  2. 02
    Wang Y5 papers · 2026

    Clinical Molecular Diagnosis Center, Taihe Hospital, Hubei University of Medicine, 32 Renmin South Road, Maojian District, Shiyan 442000, Hubei, PR China. Electronic address: 78460820@qq.com.

    Papers in Europe PMC
  3. 03
    Agarwal R4 papers · 2026

    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, (PGIMER), Chandigarh  India.

    Papers in Europe PMC
  4. 04
    Muthu V4 papers · 2026

    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, (PGIMER), Chandigarh  India.

    Papers in Europe PMC
  5. 05
    Zhang R4 papers · 2026

    Department of Infectious Disease and Hepatic Disease, First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, China.

    Papers in Europe PMC
  6. 06
    Kaur J3 papers · 2026

    Department of Ophthalmology, Minto Ophthalmic Hospital, Bangalore Medical College and Research Institute, Bengaluru, India.

    Papers in Europe PMC
  7. 07
    Kontoyiannis DP3 papers · 2026

    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

    Papers in Europe PMC
  8. 08
    Lagrou K3 papers · 2026

    Department of Microbiology Immunology and Transplantation, KU Leuven, Leuven, Belgium.

    Papers in Europe PMC
  9. 09
    Lewis RE3 papers · 2026

    Department of Molecular Medicine, University of Padua, Padua 35121, Italy.

    Papers in Europe PMC
  10. 10
    Li Y3 papers · 2026

    Department of Thoracic Surgery, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Beijing, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

14

interventional trials for this specific condition

14 interventional trials matched this specific condition name; 4 currently recruiting in our sample.

Data as of 11 September 2026

14 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.7th percentile).

low confidence · 93.7th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

14 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

19 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Zygomycosis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Zygomycosis" OR "Mucormycosis" OR "Zygomycota infectious disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Mucormycosis; Zygomycosis

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Zygomycosis" OR "Mucormycosis" OR "Zygomycota infectious disease"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 14 interventional · 19 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (15925) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T01:44:38.136Z