ORPHA:724
Idiopathic acute eosinophilic pneumonia
Also known as: IAEP
Publications
1,647
Trials
0
Interventional, condition-specific
Researchers
1,015
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
acute eosinophilic pneumonia (IAEP) is an eosinophilic pneumonia of undetermined that is characterized by acute febrile hypoxic respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia, but without concurring allergy or infection.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019122
- UMLS:C4518469
- NCIT:C35301
Additional Mondo synonyms (5)
Acute Eosinophilic Pneumonia · Loeffler syndrome · Loffler syndrome · Loffler's syndrome · Löffler syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,647 matched papers (899 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 1 for broader category eosinophilic pneumonia
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,647
1,647 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,647 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
899 in the last 10 years · low confidence
Phrase hits: 1,647 · MeSH hits: 0
Who's working on it?
1,015
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Wang X4 papers · 2026
Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Papers in Europe PMC - 02Cottin V3 papers · 2023
Service de pneumologie, Hospices Civils de Lyon, Centre de référence national des maladies pulmonaires rares, Hôpital Louis Pradel, Lyon Cedex 69677, France. vincent.cottin@chu-lyon.fr
Papers in Europe PMC - 03Li H3 papers · 2026
College of Medicine, University of Florida, Gainesville, USA.
Papers in Europe PMC - 04
- 05Barmaimon G2 papers · 2024
Department of Pulmonary and Critical Care, Hackensack University Medical Center, Hackensack, NJ, USA.
Papers in Europe PMC - 06Bodart E2 papers · 2025
Service de Pneumologie pédiatrique, CHU UCL Namur (site de Dinant), Belgique.
Papers in Europe PMC - 07Bonnier A2 papers · 2023
Department of Critical Care Nursing, Goldfarb School of Nursing, Barnes Jewish College, Saint Louis, Missouri, USA.
Papers in Europe PMC - 08Cagnetta A2 papers · 2026
Clinic of Hematology, IRCCS Azienda Ospedaliera Metropolitana, Ospedale Policlinico San Martino, Genoa, Italy.
Papers in Europe PMC - 09Catini ME2 papers · 2026
Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Papers in Europe PMC - 10Cea M2 papers · 2026
Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy. michele.cea@unige.it.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 1 trial are registered for eosinophilic pneumonia, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
1 interventional trial matched eosinophilic pneumonia, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: eosinophilic pneumonia
1
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic acute eosinophilic pneumonia" OR "Acute Eosinophilic Pneumonia" OR "Loeffler syndrome" OR "Loffler syndrome" OR "Loffler's syndrome" OR "Löffler syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic acute eosinophilic pneumonia" OR "Acute Eosinophilic Pneumonia" OR "Loeffler syndrome" OR "Loffler syndrome" OR "Loffler's syndrome" OR "Löffler syndrome"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"eosinophilic pneumonia"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: IAEP
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (1647) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-26T15:03:12.335Z