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ORPHA:71274

Disseminated peritoneal leiomyomatosis

low confidenceDisorder

Also known as: DPL · Diffuse peritoneal leiomyomatosis · LPD · Leiomyomatosis peritonealis disseminate

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

938

Trials

0

Interventional, condition-specific

Researchers

977

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Disseminated peritoneal leiomyomatosis (DPL) is characterized by the proliferation of multiple benign smooth muscle cell-containing nodules in the peritoneal cavity.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

diffuse peritoneal leiomyomatosis · disseminated peritoneal leiomyomatosis · leiomyomatosis peritonealis disseminata · leiomyomatosis peritonealis disseminate

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    938 matched papers (473 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPartial

    None under the specific name; 10 for broader category leiomyomatosis

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

938

938 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

938 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

473 in the last 10 years · low confidence

Phrase hits: 938 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

977

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Chen L4 papers · 2022

    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China. qllijunchen@163.com.

    Papers in Europe PMC
  2. 02
    Wang Y4 papers · 2026

    Department of Pathology, University of Virginia, Charlottesville, VA, USA.

    Papers in Europe PMC
  3. 03
    Yang L4 papers · 2025

    Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing, China.

    Papers in Europe PMC
  4. 04
    Chen J3 papers · 2026

    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China.

    Papers in Europe PMC
  5. 05
    Hartmann A3 papers · 2026

    Department of Obstetrics and Gynecology, ChristianaCare Health Systems, Newark, Delaware (Drs. Hartmann, Swartz, and Pacis). Electronic address: abigail.hartmann@christianacare.org.

    Papers in Europe PMC
  6. 06
    Ma R3 papers · 2025

    Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.

    Papers in Europe PMC
  7. 07
    Sharma S3 papers · 2026

    Department of Radiology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL 32209, USA.

    Papers in Europe PMC
  8. 08
    Wang C3 papers · 2025

    Department of Gynecology, Aerospace Center Hospital, Beijing, 100049, China.

    Papers in Europe PMC
  9. 09
    Wang X3 papers · 2024

    Department of Pathology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China.

    Papers in Europe PMC
  10. 10
    Zhang Y3 papers · 2023

    Medical Image Centre, Northwest Women's and Children's Hospital, Xi'an, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 10 trials are registered for leiomyomatosis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

low confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

10 interventional trials matched leiomyomatosis, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: leiomyomatosis

10

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Disseminated peritoneal leiomyomatosis" OR "Diffuse peritoneal leiomyomatosis" OR "Leiomyomatosis peritonealis disseminate" OR "leiomyomatosis peritonealis disseminata"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Disseminated peritoneal leiomyomatosis" OR "Diffuse peritoneal leiomyomatosis" OR "Leiomyomatosis peritonealis disseminate" OR "leiomyomatosis peritonealis disseminata" OR "peritoneal benign neoplasm"

Recall-expansion terms: peritoneal benign neoplasm

Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"leiomyomatosis"

Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: DPL; LPD

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 2 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (938) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T01:40:05.310Z