ORPHA:70587
Infant acute respiratory distress syndrome
Also known as: Hyaline membrane disease · Infant ARDS · Infant respiratory distress syndrome · Neonatal respiratory distress syndrome
Publications
10,119
Trials
51
Interventional, condition-specific
Researchers
887
Distinct authors in sample
Gene link
—
Readiness
4/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0009971
- MeSH:C566881
- OMIM:267450
- UMLS:C1968593
Additional Mondo synonyms (3)
RDS of prematurity · Respiratory Distress Syndrome, Infant · respiratory distress syndrome in premature infants
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
4/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
10,119 matched papers (3,526 in last 10 years) Source
- Phenotype characterisedPresent
9 HPO annotations (e.g. Pulmonary edema; Disseminated intravascular coagulation; Edema) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationPresent
1 FDA designation (1 FDA orphan-indication approval) — e.g. Lucinactant Source
- Interventional trialPresent
51 matched on ClinicalTrials.gov (10 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
9
Associated phenotypes · MONDO:0009971
- Pulmonary edema
- Disseminated intravascular coagulation
- Edema
- Respiratory distress
- Atelectasis
Showing 5 of 9 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
1
Designation · 1 with FDA orphan-indication approval
- FDA LucinactantRespiratory Distress Syndrome In Premature Infants · 1995-10-18 · Not FDA Approved for Orphan Indication
Sources: FDA OOPD · EMA orphan designations
Open Targets candidates
21
Drugs / clinical candidates · MONDO_0009971
- CALFACTANT·phase 3
- INDOMETHACIN·phase 3
- KETAMINE·phase 3
- NITRIC OXIDE·phase 3
- PROPOFOL·phase 3
- RETINOL·phase 3
- DEXAMETHASONE·phase 2
- BOVACTANT·phase 1
- BERACTANT·approval
- BETAMETHASONE·unknown
- BUDESONIDE·phase 1 2
- CARNITINE·unknown
- COLFOSCERIL PALMITATE·approval
- FENTANYL·unknown
- IBUPROFEN·phase 2 3
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
10,119
10,119 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
10,119 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
3,526 in the last 10 years · low confidence
Phrase hits: 10,119 · MeSH hits: 13
Who's working on it?
887
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Zhang Y13 papers · 2026
Department of Neonatology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Papers in Europe PMC - 02Li J10 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 03Li Y10 papers · 2026
The First People's Hospital of Neijiang, Department of Pediatrics, Neijiang, Sichuan, China.
Papers in Europe PMC - 04Wang Y10 papers · 2026
Department of Obstetrics and Gynecology, Hangzhou Women's Hospital, No. 369 Kunpeng Road, Hangzhou, Zhejiang, 310008, P. R. of China.
Papers in Europe PMC - 05Zhang X10 papers · 2026
Department of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China. icy.zhang@163.com.
Papers in Europe PMC - 06Zhang J9 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 07Liu Y8 papers · 2026
Department of Pediatrics, The Ethnic Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Papers in Europe PMC - 08Zhang L7 papers · 2026
Department of Pediatrics, Pu'er People's Hospital, 665000 Pu'er, Yunnan, China.
Papers in Europe PMC - 09Chen H6 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 10Li S6 papers · 2026
School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
51
interventional trials for this specific condition
51 interventional trials matched this specific condition name; 10 currently recruiting in our sample.
Data as of 11 September 2026
51 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 97.2th percentile).
low confidence · 97.2th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
51 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06554522·RECRUITING·Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
Not reviewed·Conditions: Respiratory Distress Syndrome in Premature Infant · RDS of Prematurity · Surfactant Deficiency Syndrome Neonatal · Premature Birth·Matched via name phrase
- NCT07100652·NOT YET RECRUITING·Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants
Not reviewed·Conditions: Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease])·Matched via name phrase
- NCT06975189·RECRUITING·MINImising Total Radiation EXposure in Preterm Infants
Not reviewed·Conditions: Neonatal Respiratory Distress Syndrome · PreTerm Neonate·Matched via name phrase
- NCT06757543·RECRUITING·A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants
Not reviewed·Conditions: Intubation · Intubation Complications · Infant, Newborn · Infant Respiratory Distress Syndrome·Matched via name phrase
- NCT04445571·RECRUITING·Surfactant Administration by Insure or Thin Catheter
Not reviewed·Conditions: RDS of Prematurity · Surfactant Deficiency Syndrome Neonatal · Analgesia·Matched via name phrase
- NCT07350018·RECRUITING·Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome
Not reviewed·Conditions: Respiratory Distress Syndrome in Premature Infants · Respiratory Distress Syndrome (RDS) · Surfactant·Matched via name + MeSH
- NCT07377955·NOT YET RECRUITING·Combined Oscillation-Volume guarantEe Study
Not reviewed·Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) · Bronchopulmonary Dysplasia (BPD)·Matched via name phrase
- NCT07261787·RECRUITING·Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Not reviewed·Conditions: Neonates and Preterm Infants · Infant Respiratory Distress Syndrome · Surfactant Deficiency Syndrome Neonatal · Surfactant·Matched via name phrase
- NCT07235345·ENROLLING BY INVITATION·To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
Not reviewed·Conditions: Neonatal Respiratory Distress Syndrome·Matched via name phrase
- NCT07060911·NOT YET RECRUITING·Pivotal Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates
Not reviewed·Conditions: RDS of Prematurity · Preterm Birth · Lung Diseases·Matched via name phrase
Observational and natural-history studies
22 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT04777760·RECRUITING·Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
Not reviewed·Conditions: Respiratory Distress Syndrome · Preterm Birth · Acute Respiratory Distress Syndrome · Surfactant Dysfunction·Matched via name phrase
- NCT07344714·RECRUITING·Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
Not reviewed·Conditions: Respiratory Distress Syndrome, Newborn · Respiratory Distress Syndrome in Premature Infant · Transient Tachypnea of the Newborn · Meconium Aspiration Syndrome·Matched via name phrase
- NCT07550218·NOT YET RECRUITING·Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
Not reviewed·Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) · Respiratory Distress Syndrome (Neonatal) · Respiratory Distress Syndrome (RDS) · Respiratory Distress Syndrome of Newborn·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 12 · after dedupe 12 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 12 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (12)
- ctis·2024-516461-36-00·Authorised, ongoing·CHASAP : Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy, a multicenter prospective randomized double-blind placebo-controlled trial.
skipped — LLM skipped (--skip-llm)
- ctis·2022-500293-34-01·Authorised, recruiting·Phase I single arm, dose escalating and phase II double blind, randomized, placebo-controlled dose finding clinical trial assessing safety, and efficacy of intratracheal administration of allogeneic umbilical mesenchymal cells-derived extracellular vesicles in preventing bronchopulmonary dysplasia in extremely preterm newborns.
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN12057804·Recruiting·A study of nipocalimab in pregnancies for severe hemolytic disease of the fetus and newborn (HDFN)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN21187408·No longer recruiting·A study assessing clinical aspects of pregnancy, delivery and perinatal outcomes in women with intrahepatic cholestasis of pregnancy
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN12331315·No longer recruiting·Optimisation of invasive breathing support in newborns by continuous carbon dioxide monitoring
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN32082979·No longer recruiting·Treatment of restriction in fetal growth with L-arginine
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN16018898·No longer recruiting·OPTIMUM: Optimising titration and monitoring of maternal blood pressure
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN40973936·No longer recruiting·Pregnancy and chronic hypertension; nifedipine or labetalol as anti-hypertensive treatment
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN13184012·No longer recruiting·Prevention of hypothermia, in the immediate neonatal period, in infants with gestational age ≤28 weeks: a comparative study of the effectiveness of two models of polyethylene bags
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN15346559·No longer recruiting·Process for decision-making, obstetrical risk management and mode of delivery after a prior cesarean delivery in Québec
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN46157068·Recruiting·Identifying candidates for early respiratory failure treatment based on Interleukin-6 levels
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN35456296·No longer recruiting·Right from the start: Improving outcomes for children born to mothers in difficult circumstances
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Infant acute respiratory distress syndrome — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Infant acute respiratory distress syndrome" OR "Hyaline membrane disease" OR "Infant ARDS" OR "Infant respiratory distress syndrome" OR "Neonatal respiratory distress syndrome" OR "RDS of prematurity" OR "RDS of the prematurity" OR "Respiratory Distress Syndrome, Infant" OR "respiratory distress syndrome in premature infants"
MeSH descriptor terms unioned into the query: Respiratory Distress Syndrome In Premature Infants
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Infant acute respiratory distress syndrome" OR "Hyaline membrane disease" OR "Infant ARDS" OR "Infant respiratory distress syndrome" OR "Neonatal respiratory distress syndrome" OR "RDS of prematurity" OR "RDS of the prematurity" OR "Respiratory Distress Syndrome, Infant" OR "respiratory distress syndrome in premature infants"
Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 51 interventional · 22 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (10119) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T01:35:21.038Z