ORPHA:70587
Infant acute respiratory distress syndrome
Also known as: Hyaline membrane disease · Infant ARDS · Infant respiratory distress syndrome · Neonatal respiratory distress syndrome
Publications
10,119
Trials
51
Interventional, condition-specific
Researchers
887
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0009971
- MeSH:C566881
- OMIM:267450
- UMLS:C1968593
Additional Mondo synonyms (3)
RDS of prematurity · Respiratory Distress Syndrome, Infant · respiratory distress syndrome in premature infants
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
10,119 matched papers (3,526 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
51 matched on ClinicalTrials.gov (10 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
10,119
10,119 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
10,119 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
3,526 in the last 10 years · low confidence
Phrase hits: 10,119 · MeSH hits: 13
Who's working on it?
887
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Zhang Y13 papers · 2026
Department of Neonatology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Papers in Europe PMC - 02Li J10 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 03Li Y10 papers · 2026
The First People's Hospital of Neijiang, Department of Pediatrics, Neijiang, Sichuan, China.
Papers in Europe PMC - 04Wang Y10 papers · 2026
Department of Obstetrics and Gynecology, Hangzhou Women's Hospital, No. 369 Kunpeng Road, Hangzhou, Zhejiang, 310008, P. R. of China.
Papers in Europe PMC - 05Zhang X10 papers · 2026
Department of Pediatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China. icy.zhang@163.com.
Papers in Europe PMC - 06Zhang J9 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 07Liu Y8 papers · 2026
Department of Pediatrics, The Ethnic Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Papers in Europe PMC - 08Zhang L7 papers · 2026
Department of Pediatrics, Pu'er People's Hospital, 665000 Pu'er, Yunnan, China.
Papers in Europe PMC - 09Chen H6 papers · 2026
Department of Neonatology, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, Henan, China.
Papers in Europe PMC - 10Li S6 papers · 2026
School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
51
interventional trials for this specific condition
51 interventional trials matched this specific condition name; 10 currently recruiting in our sample.
Data as of 27 July 2026
51 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 97.1th percentile).
low confidence · 97.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
51 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06554522·RECRUITING·Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
Conditions: Respiratory Distress Syndrome in Premature Infant · RDS of Prematurity · Surfactant Deficiency Syndrome Neonatal · Premature Birth·Matched via name phrase
- NCT07100652·NOT YET RECRUITING·Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants
Conditions: Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease])·Matched via name phrase
- NCT06975189·RECRUITING·MINImising Total Radiation EXposure in Preterm Infants
Conditions: Neonatal Respiratory Distress Syndrome · PreTerm Neonate·Matched via name phrase
- NCT06757543·RECRUITING·A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants
Conditions: Intubation · Intubation Complications · Infant, Newborn · Infant Respiratory Distress Syndrome·Matched via name phrase
- NCT04445571·RECRUITING·Surfactant Administration by Insure or Thin Catheter
Conditions: RDS of Prematurity · Surfactant Deficiency Syndrome Neonatal · Analgesia·Matched via name phrase
- NCT07350018·RECRUITING·Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome
Conditions: Respiratory Distress Syndrome in Premature Infants · Respiratory Distress Syndrome (RDS) · Surfactant·Matched via name + MeSH
- NCT07377955·NOT YET RECRUITING·Combined Oscillation-Volume guarantEe Study
Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) · Bronchopulmonary Dysplasia (BPD)·Matched via name phrase
- NCT07261787·RECRUITING·Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Conditions: Neonates and Preterm Infants · Infant Respiratory Distress Syndrome · Surfactant Deficiency Syndrome Neonatal · Surfactant·Matched via name phrase
- NCT07235345·ENROLLING BY INVITATION·To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
Conditions: Neonatal Respiratory Distress Syndrome·Matched via name phrase
- NCT07060911·NOT YET RECRUITING·Pivotal Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates
Conditions: RDS of Prematurity · Preterm Birth · Lung Diseases·Matched via name phrase
Observational and natural-history studies
22 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT04777760·RECRUITING·Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
Conditions: Respiratory Distress Syndrome · Preterm Birth · Acute Respiratory Distress Syndrome · Surfactant Dysfunction·Matched via name phrase
- NCT07344714·RECRUITING·Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
Conditions: Respiratory Distress Syndrome, Newborn · Respiratory Distress Syndrome in Premature Infant · Transient Tachypnea of the Newborn · Meconium Aspiration Syndrome·Matched via name phrase
- NCT07550218·NOT YET RECRUITING·Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) · Respiratory Distress Syndrome (Neonatal) · Respiratory Distress Syndrome (RDS) · Respiratory Distress Syndrome of Newborn·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Infant acute respiratory distress syndrome" OR "Hyaline membrane disease" OR "Infant ARDS" OR "Infant respiratory distress syndrome" OR "Neonatal respiratory distress syndrome" OR "RDS of prematurity" OR "RDS of the prematurity" OR "Respiratory Distress Syndrome, Infant" OR "respiratory distress syndrome in premature infants"
MeSH descriptor terms unioned into the query: Respiratory Distress Syndrome In Premature Infants
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Infant acute respiratory distress syndrome" OR "Hyaline membrane disease" OR "Infant ARDS" OR "Infant respiratory distress syndrome" OR "Neonatal respiratory distress syndrome" OR "RDS of prematurity" OR "RDS of the prematurity" OR "Respiratory Distress Syndrome, Infant" OR "respiratory distress syndrome in premature infants"
Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 51 interventional · 22 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (10119) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T01:35:21.038Z