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ORPHA:70578

Adult acute respiratory distress syndrome

high confidenceDisorder

Also known as: Adult ARDS

Publications

17,491

98.3th percentile

Trials

979

Interventional, condition-specific

Researchers

1,130

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%.

How rare: 6-9 / 10 000

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (5)

adult ARDS · adult acute respiratory distress syndrome · adult respiratory distress syndrome · adult respiratory distress syndrome, ARDS · respiratory distress syndrome, adult

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    17,491 matched papers (7,937 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    979 matched on ClinicalTrials.gov (169 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

17,491

17,491 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

17,491 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

7,937 in the last 10 years · high confidence · 98.3th percentile (publications denominator)

Phrase hits: 12,300 · MeSH hits: 5,587

Open Europe PMC search

Who's working on it?

1,130

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang H7 papers · 2026

    Department of Rehabilitation Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

    Papers in Europe PMC
  2. 02
    Li J3 papers · 2026

    School of Clinical Medicine & The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

    Papers in Europe PMC
  3. 03
    Li R3 papers · 2025

    Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

    Papers in Europe PMC
  4. 04
    Li W3 papers · 2026

    Department of Hematology and Oncology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410000, China.

    Papers in Europe PMC
  5. 05
    Li Z3 papers · 2025

    School of Graduate, Chengde Medical University, Chengde, China.

    Papers in Europe PMC
  6. 06
    Liu D3 papers · 2026

    Department of Respiratory and Critical Care Medicine, The Fourth Hospital of Changsha, Changsha, Hunan, China.

    Papers in Europe PMC
  7. 07
    Liu Y3 papers · 2026

    Department of Rehabilitation Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

    Papers in Europe PMC
  8. 08
    Wang B3 papers · 2025

    Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.

    Papers in Europe PMC
  9. 09
    Wang X3 papers · 2026

    Department of Clinical Medical, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.

    Papers in Europe PMC
  10. 10
    Zhang Z3 papers · 2026

    The First Clinical Medical College, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, China, gmu.cn.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

979

interventional trials for this specific condition

979 interventional trials matched this specific condition name; 169 currently recruiting in our sample.

Data as of 27 July 2026

979 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 99.9th percentile).

high confidence · 99.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

979 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: acute respiratory distress syndrome

0

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Parent-category matching found a broader label but no interventional trials under it. How we count trials.

Observational and natural-history studies

512 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Adult acute respiratory distress syndrome" OR "Adult ARDS" OR "adult respiratory distress syndrome" OR "adult respiratory distress syndrome, ARDS" OR "respiratory distress syndrome, adult"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Respiratory Distress Syndrome

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Adult acute respiratory distress syndrome" OR "Adult ARDS" OR "adult respiratory distress syndrome" OR "adult respiratory distress syndrome, ARDS" OR "respiratory distress syndrome, adult" OR "Respiratory Distress Syndrome"

Interventional trials matched via: both, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 979 interventional · 512 observational · 3 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"acute respiratory distress syndrome"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T01:34:41.921Z