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ORPHA:704

Pemphigus vulgaris

high confidenceDisorder

Publications

9,778

97.5th percentile

Trials

34

Interventional, condition-specific

Researchers

999

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare autoimmune bullous skin diseases characterized by painful, flaccid blisters and erosions of the oral mucosa, predominantly involving the buccal area, and with or without extension to the epidermis. Mucosa of the larynx, oesophagus, conjunctiva, nose, genitalia and anus, are less frequently affected.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    9,778 matched papers (4,958 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    34 matched on ClinicalTrials.gov (6 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

9,778

9,778 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

9,778 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

4,958 in the last 10 years · high confidence · 97.5th percentile (publications denominator)

Phrase hits: 9,778 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

999

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Gupta S5 papers · 2026

    Department of Dermatology, Civil Hospital, Nabha, Punjab, India.

    Papers in Europe PMC
  2. 02
    Balighi K4 papers · 2026

    Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran. kamran.balighi@yahoo.com.

    Papers in Europe PMC
  3. 03
    Daneshpazhooh M4 papers · 2026

    Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

    Papers in Europe PMC
  4. 04
    Li X4 papers · 2026

    Nursing Department, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; (X.Z.);

    Papers in Europe PMC
  5. 05
    Schmidt E4 papers · 2026

    Department of Dermatology, University of Lübeck, Lübeck, Germany. enno.schmidt@uksh.de.

    Papers in Europe PMC
  6. 06
    Sharma A4 papers · 2026

    Department of Biochemistry, AIIMS, New Delhi, India.

    Papers in Europe PMC
  7. 07
    Arava S3 papers · 2026

    Department of Pathology, AIIMS, New Delhi, India.

    Papers in Europe PMC
  8. 08
    Ebrahimpour-Koujan S3 papers · 2026

    Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No: 44, Hojjat-dost Alley, Naderi St., Keshavarz Blvd, PO Box: 14155-6117, Tehran, Iran. nutri.seam1@gmail.com.

    Papers in Europe PMC
  9. 09
    Hashimoto T3 papers · 2026

    Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

    Papers in Europe PMC
  10. 10
    Hertl M3 papers · 2026

    Department of Dermatology and Allergology, Philipps University, Marburg, Germany.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

34

interventional trials for this specific condition

34 interventional trials matched this specific condition name; 6 currently recruiting in our sample. 21 trials are registered for pemphigus, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

34 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 96th percentile).

high confidence · 96th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

34 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: pemphigus

21

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

11 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Pemphigus vulgaris"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Pemphigus vulgaris"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 34 interventional · 11 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"pemphigus"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T14:58:03.294Z