ORPHA:699697
Necrotizing fasciitis
Publications
13,892
Trials
8
Interventional, condition-specific
Researchers
916
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
13,892 matched papers (8,072 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
8 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
13,892
13,892 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
13,892 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
8,072 in the last 10 years · low confidence
Phrase hits: 13,892 · MeSH hits: 0
Who's working on it?
916
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Li X6 papers · 2026
Department of Plastic and Cosmetic surgery and Burns, Qilu Hospital of Shandong University, Jinan, China.
Papers in Europe PMC - 02Wang X6 papers · 2026
Department of Hematology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University Tianjin 300121, China.
Papers in Europe PMC - 03Wang L4 papers · 2026
Department of Medical, Southeast University, 87 Dingjiaqiao street, Nanjing, Jiangsu Province, China.
Papers in Europe PMC - 04Chen Z3 papers · 2026
Department of Colorectal Surgery, Nanjing Hosipital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Daming Road, Qin Huai District, Nanjing, Jiangsu, 210022, China.
Papers in Europe PMC - 05Fukushima S3 papers · 2026
Department of Infectious Diseases, Okayama University Hospital, Japan.
Papers in Europe PMC - 06Hagiya H3 papers · 2026
Department of Infectious Diseases, Okayama University Hospital, Japan.
Papers in Europe PMC - 07Li W3 papers · 2026
Department of Dermatology, Peking University Third Hospital, Haidian District, Beijing.
Papers in Europe PMC - 08Li Y3 papers · 2026
Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Papers in Europe PMC - 09Liu Y3 papers · 2026
Department of Endocrinology, Peking University Third Hospital, Haidian District, Beijing.
Papers in Europe PMC - 10Rothstein JL3 papers · 2026Papers in Europe PMC
Clinical research
Is a treatment being tested?
8
interventional trials for this specific condition
8 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).
low confidence · 90.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
8 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07170020·NOT YET RECRUITING·Hyperbaric Oxygen Treatment for Necrotizing Fasciitis and Necrotizing Soft Tissue Infections
Conditions: Necrotizing Fascitis·Matched via name phrase
Observational and natural-history studies
11 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Necrotizing fasciitis"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Necrotizing fasciitis"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 8 interventional · 11 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- No Orphanet definition and no Mondo IDs — likely taxonomy scaffolding; confidence capped at low
Ingested 2026-07-27T20:52:15.089Z