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ORPHA:69665

Intrahepatic cholestasis of pregnancy

low confidence

Also known as: Gravidic intrahepatic cholestasis · Pregnancy-related cholestasis · Recurrent intrahepatic cholestasis of pregnancy

Clinical definition (Orphanet)

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery.

How rare: How common this is has not been clearly measured.

Orphanet entry

Is anyone studying this?

4,080

4,080 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.

4,080 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).

2,890 in the last 10 years · low confidence

Is a treatment being tested?

9

trials for this specific condition

9 interventional trials matched this specific condition name; 2 currently recruiting in our sample. 15 trials are registered for intrahepatic cholestasis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 26 July 2026

15

trials for intrahepatic cholestasis, the broader category this belongs to

Trials registered for a broader category may or may not enrol people with this specific subtype — eligibility criteria vary, and the trial record often doesn't say. Worth raising with a clinician. How we count trials.

9 interventional trials — more than 59.2% of diseases in the trials denominator have none at all (151 of 255; this disease is at the 85.9th percentile).

low confidence · 85.9th percentile (trials denominator)

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Who's working on it?

996

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Williamson C10 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.

    Papers in Europe PMC
  2. 02
    Zhang L10 papers · 2026

    Department of Gynecology, Yue yang Hospital of Integrated Traditiona l Chinese and Western Medicine, Shanghai University of Traditional Chin ese Medicine, Shanghai, China.

    Papers in Europe PMC
  3. 03
    Wang J8 papers · 2026

    Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, 251 Yaojiayuan Road, Beijing, 100026, China.

    Papers in Europe PMC
  4. 04
    Gao J7 papers · 2026

    Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  5. 05
    Chambers J6 papers · 2026

    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK; Women's Health Research Centre, Imperial College London, London, UK.

    Papers in Europe PMC
  6. 06
    Ovadia C6 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. Electronic address: covadia@ed.ac.uk.

    Papers in Europe PMC
  7. 07
    Yang X6 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.

    Papers in Europe PMC
  8. 08
    Zhang T6 papers · 2026

    Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  9. 09
    Zhang Y6 papers · 2026

    Information Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

    Papers in Europe PMC
  10. 10
    Chen J5 papers · 2026

    Department of Radiology, Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou, Zhejiang, China.

    Papers in Europe PMC

Recruiting interventional trials

Trials testing a treatment from the matched ClinicalTrials.gov set

9 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

18 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.

"Intrahepatic cholestasis of pregnancy" OR "Gravidic intrahepatic cholestasis" OR "Pregnancy-related cholestasis" OR "Recurrent intrahepatic cholestasis of pregnancy" OR "pregnancy related cholestasis"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Intrahepatic Cholestasis of Pregnancy

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Intrahepatic cholestasis of pregnancy" OR "Intrahepatic cholestasis of the pregnancy" OR "Gravidic intrahepatic cholestasis" OR "Pregnancy-related cholestasis" OR "Recurrent intrahepatic cholestasis of pregnancy" OR "Recurrent intrahepatic cholestasis of the pregnancy" OR "pregnancy related cholestasis"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 9 interventional · 18 observational · 0 expanded access. Only interventional studies enter the trial headline.

Cross-references (from Mondo): MESH:C535932 UMLS:C0268318

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (4080) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

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