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ORPHA:69665

Intrahepatic cholestasis of pregnancy

low confidenceDisorder

Also known as: Gravidic intrahepatic cholestasis · Pregnancy-related cholestasis · Recurrent intrahepatic cholestasis of pregnancy

Publications

4,080

Trials

9

Interventional, condition-specific

Researchers

996

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (5)

gravidic intrahepatic cholestasis · intrahepatic cholestasis of pregnancy · pregnancy related cholestasis · pregnancy-related cholestasis · recurrent intrahepatic cholestasis of pregnancy

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    4,080 matched papers (2,890 in last 10 years) Source

  3. Phenotype characterisedPresent

    41 HPO annotations (e.g. Hypothyroidism; Ascites; Premature birth) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    9 matched on ClinicalTrials.gov (2 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

41

Associated phenotypes · MONDO:0100429

  • Hypothyroidism
  • Ascites
  • Premature birth
  • Abdominal pain
  • Asterixis

Showing 5 of 41 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

2 associated chemicals · 85 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Ursodeoxycholic Acid · therapeutic
  • epiallopregnanolone sulfate · marker/mechanism

Pathways: Antifolate resistance; ABC transporters; MAPK signaling pathway; Cytokine-cytokine receptor interaction; NF-kappa B signaling pathway; Sphingolipid signaling pathway; mTOR signaling pathway; Apoptosis

MyDisease.info · MONDO:0100429

Literature

Is anyone studying this?

4,080

4,080 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

4,080 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

2,890 in the last 10 years · low confidence

Phrase hits: 4,080 · MeSH hits: 111

Open Europe PMC search

Who's working on it?

996

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Williamson C10 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.

    Papers in Europe PMC
  2. 02
    Zhang L10 papers · 2026

    Department of Gynecology, Yue yang Hospital of Integrated Traditiona l Chinese and Western Medicine, Shanghai University of Traditional Chin ese Medicine, Shanghai, China.

    Papers in Europe PMC
  3. 03
    Wang J8 papers · 2026

    Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, 251 Yaojiayuan Road, Beijing, 100026, China.

    Papers in Europe PMC
  4. 04
    Gao J7 papers · 2026

    Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  5. 05
    Chambers J6 papers · 2026

    Institute of Reproductive and Developmental Biology, Imperial College London, London, UK; Women's Health Research Centre, Imperial College London, London, UK.

    Papers in Europe PMC
  6. 06
    Ovadia C6 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. Electronic address: covadia@ed.ac.uk.

    Papers in Europe PMC
  7. 07
    Yang X6 papers · 2026

    Department of Women and Children's Health, King's College London, London, UK; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.

    Papers in Europe PMC
  8. 08
    Zhang T6 papers · 2026

    Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  9. 09
    Zhang Y6 papers · 2026

    Information Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

    Papers in Europe PMC
  10. 10
    Chen J5 papers · 2026

    Department of Radiology, Hangzhou Medical College, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou, Zhejiang, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

9

interventional trials for this specific condition

9 interventional trials matched this specific condition name; 2 currently recruiting in our sample. 15 trials are registered for intrahepatic cholestasis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 9 September 2026

9 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 92th percentile).

low confidence · 92th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

9 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: intrahepatic cholestasis

15

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

18 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 6 · after dedupe 6 · already on CT.gov 0 · kept 2 · parent 0 · uncertain 0 · dropped 4 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Intrahepatic cholestasis of pregnancy — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Intrahepatic cholestasis of pregnancy" OR "Gravidic intrahepatic cholestasis" OR "Pregnancy-related cholestasis" OR "Recurrent intrahepatic cholestasis of pregnancy" OR "pregnancy related cholestasis"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Intrahepatic Cholestasis of Pregnancy

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Intrahepatic cholestasis of pregnancy" OR "Intrahepatic cholestasis of the pregnancy" OR "Gravidic intrahepatic cholestasis" OR "Pregnancy-related cholestasis" OR "Recurrent intrahepatic cholestasis of pregnancy" OR "Recurrent intrahepatic cholestasis of the pregnancy" OR "pregnancy related cholestasis"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 9 interventional · 18 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"intrahepatic cholestasis"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (4080) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T02:34:45.047Z