RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:69078

Liposarcoma

low confidenceDisorder

Publications

24,023

Trials

134

Interventional, condition-specific

Researchers

1,319

Distinct authors in sample

Gene link

—

Readiness

5/6

Stages with a signal

Clinical definition (Orphanet)

Liposarcoma (LS), a type of soft tissue sarcoma, describes a group of lipomatous tumors of varying severity ranging from slow-growing to aggressive and metastatic. Liposarcomas are most often located in the lower extremities or retroperitoneum, but they can also occur in the upper extremities, neck, peritoneal cavity, spermatic cord, breast, vulva and axilla.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

lip sarcoma · liposarcoma · liposarcoma, malignant · sarcoma of lip

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

5/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    24,023 matched papers (13,158 in last 10 years) Source

  3. Phenotype characterisedPresent

    19 HPO annotations (e.g. Myxoid liposarcoma; Subcutaneous nodule; Abdominal pain) Source

  4. Animal modelPresent

    2 genotype models (Mus musculus) Source

  5. Orphan designationPresent

    1 FDA designation (1 FDA orphan-indication approval) — e.g. milademetan Source

  6. Interventional trialPresent

    134 matched on ClinicalTrials.gov (31 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

19

Associated phenotypes · MONDO:0005060

  • Myxoid liposarcoma
  • Subcutaneous nodule
  • Abdominal pain
  • Gastrointestinal dysmotility

Showing 4 of 19 — open Monarch for the full list.

Animal models (Monarch / Alliance)

2

Model associations linked to this Mondo ID

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · 1 with FDA orphan-indication approval

  • FDA milademetanliposarcoma · 2017-02-13 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

45

Drugs / clinical candidates · MONDO_0005060

CTD chemicals (MyDisease.info)

8 associated chemicals · 125 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • MAID protocol · therapeutic
  • Nelfinavir · therapeutic
  • Paclitaxel · therapeutic
  • palbociclib · therapeutic
  • Sorafenib · therapeutic
  • Troglitazone · therapeutic
  • muraglitazar · marker/mechanism
  • naveglitazar · marker/mechanism

Pathways: Fatty acid biosynthesis; Metabolic pathways; Fatty acid metabolism; EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Cell cycle

MyDisease.info · MONDO:0005060

Literature

Is anyone studying this?

24,023

24,023 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

24,023 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

13,158 in the last 10 years · low confidence

Phrase hits: 24,023 · MeSH hits: 672

Open Europe PMC search

Who's working on it?

1,319

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li W5 papers · 2026

    Department of Retroperitoneal Tumor Surgery, Peking University International Hospital, Beijing, China. Electronic address: liwenjie@pkuih.edu.cn.

    Papers in Europe PMC
  2. 02
    Li Y5 papers · 2026

    Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. zhaojc3@163.com.

    Papers in Europe PMC
  3. 03
    Wang J5 papers · 2026

    Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. zhaojc3@163.com.

    Papers in Europe PMC
  4. 04
    Gronchi A4 papers · 2026

    Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

    Papers in Europe PMC
  5. 05
    Sanfilippo R4 papers · 2026

    European Institute of Oncology Milano Italy.

    Papers in Europe PMC
  6. 06
    Tseng WW4 papers · 2026

    Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA. wtseng@coh.org.

    Papers in Europe PMC
  7. 07
    Vanzulli A4 papers · 2026

    Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

    Papers in Europe PMC
  8. 08
    Yang Z4 papers · 2026

    Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471003, China.

    Papers in Europe PMC
  9. 09
    Allajbej A3 papers · 2026

    Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

    Papers in Europe PMC
  10. 10
    Baia M3 papers · 2026

    Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

134

interventional trials for this specific condition

134 interventional trials matched this specific condition name; 31 currently recruiting in our sample.

Data as of 11 September 2026

134 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 98.9th percentile).

low confidence · 98.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

134 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

14 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 78 · after dedupe 78 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 78 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (78)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Liposarcoma — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Liposarcoma" OR "lip sarcoma" OR "liposarcoma, malignant" OR "sarcoma of lip" OR "sarcoma of the lip"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Liposarcoma

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Liposarcoma" OR "lip sarcoma" OR "liposarcoma, malignant" OR "sarcoma of lip" OR "sarcoma of the lip"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 134 interventional · 14 observational · 1 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (24023) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T01:27:36.058Z