ORPHA:680
Normokalemic periodic paralysis
Also known as: NormoKPP · NormoPP · Normokalemic PP · Periodic paralysis type 3 · Potassium-sensitive normokalemic periodic paralysis
Publications
169
Trials
0
Interventional, condition-specific
Researchers
781
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
169 matched papers (77 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
169
169 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
169 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
77 in the last 10 years · low confidence
Phrase hits: 169 · MeSH hits: 0
Who's working on it?
781
Distinct author names in 169 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Jurkat-Rott K9 papers · 2015
Division of Neurophysiology, Ulm University, Albert-Einstein-Allee 11, 89070 Ulm, Germany.
Papers in Europe PMC - 02Chahine M8 papers · 2018
Centre de Recherche de L'Institut Universitaire en Santé Mentale de Québec, Québec City, Québec G1J 2G3, Canada Department of Medicine, Université Laval, Québec City, Québec G1K 7P4, Canada mohamed.chahine@phc.ulaval.ca.
Papers in Europe PMC - 03Lehmann-Horn F8 papers · 2014
Institute of Applied Physiology, Ulm University, Ulm, Germany. frank.lehmann-horn@uni-ulm.de
Papers in Europe PMC - 04Catterall WA7 papers · 2021
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: wcatt@uw.edu.
Papers in Europe PMC - 05Hanna MG7 papers · 2019
MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.
Papers in Europe PMC - 06Cannon SC6 papers · 2024
Department of Neurology, Massachusetts General Hospital, Boston.
Papers in Europe PMC - 07Fontaine B5 papers · 2021
Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière (ICM), F-75013, Paris, France. bertrand.fontaine@sorbonne-universite.fr.
Papers in Europe PMC - 08Griggs RC5 papers · 2018
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Papers in Europe PMC - 09Kieff E5 papers · 2011Papers in Europe PMC
- 10Moreau A5 papers · 2018
Centre de Recherche de L'Institut Universitaire en Santé Mentale de Québec, Québec City, Québec G1J 2G3, Canada.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Normokalemic periodic paralysis" OR "NormoKPP" OR "NormoPP" OR "Normokalemic PP" OR "Periodic paralysis type 3" OR "Potassium-sensitive normokalemic periodic paralysis"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Normokalemic periodic paralysis" OR "NormoKPP" OR "NormoPP" OR "Normokalemic PP" OR "Periodic paralysis type 3" OR "Potassium-sensitive normokalemic periodic paralysis"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- No Orphanet definition and no Mondo IDs — likely taxonomy scaffolding; confidence capped at low
Ingested 2026-07-26T14:54:50.277Z