ORPHA:675396
Epithelioid hemangioma
Also known as: ALHE · Angiolymphoid hyperplasia with eosinophilia · EH · Epithelioid haemangioma
Publications
2,375
Trials
0
Interventional, condition-specific
Researchers
977
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0021169
- UMLS:C0205788
- NCIT:C4298
Additional Mondo synonyms (2)
epithelioid hemangioma · histiocytoid hemangioma
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
2,375 matched papers (832 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 54 for broader category hemangioma
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
2,375
2,375 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
2,375 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
832 in the last 10 years · low confidence
Phrase hits: 2,375 · MeSH hits: 0
Who's working on it?
977
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Antonescu CR3 papers · 2022
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Papers in Europe PMC - 02Ayyanar P3 papers · 2025
Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha, India.
Papers in Europe PMC - 03Linos K3 papers · 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Papers in Europe PMC - 04Mentzel T3 papers · 2025
MVZ Dermatopathologie Friedrichshafen/Bodensee, Friedrichshafen, Deutschland.
Papers in Europe PMC - 05Sethy M3 papers · 2025
Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha, India.
Papers in Europe PMC - 06Zhang L3 papers · 2025
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Papers in Europe PMC - 07Zhang X3 papers · 2025
Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Papers in Europe PMC - 08Ahmed HS2 papers · 2025
Department of Ophthalmology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
Papers in Europe PMC - 09Ansari M2 papers · 2023
Autoimmune Bullous Disease Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Papers in Europe PMC - 10
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 54 trials are registered for hemangioma, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
54 interventional trials matched hemangioma, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: hemangioma
54
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07665177·NOT YET RECRUITING·Abrupt Discontinuation Versus Gradual Tapering of Propranolol in Infantile Hemangioma
Conditions: Infantile Hemangioma (IH)·Matched via name phrase
- NCT07477548·NOT YET RECRUITING·A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies
Conditions: Vascular Malformations · Arteriovenous Malformations · Venous Malformation · Lymphangioma·Matched via name phrase
- NCT01873131·RECRUITING·A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn
Conditions: Hemangioma·Matched via name phrase
- NCT06798363·RECRUITING·Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma
Conditions: Infantile Hemangioma·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Epithelioid hemangioma" OR "Angiolymphoid hyperplasia with eosinophilia" OR "Epithelioid haemangioma" OR "histiocytoid hemangioma"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Epithelioid hemangioma" OR "Angiolymphoid hyperplasia with eosinophilia" OR "Epithelioid haemangioma" OR "histiocytoid hemangioma"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"hemangioma"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: ALHE; EH
Confidence reasoning
- Preferred label is multi-word and distinctive
- 2 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (2375) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T20:23:38.626Z