ORPHA:674968
Bilateral diffuse uveal melanocytic proliferation disease
Also known as: BDUMP · Paraneoplastic uveal melanocytic hyperplasia
Publications
135
65.1th percentile
Trials
0
Interventional, condition-specific
Researchers
629
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0971131
- UMLS:C1282144
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
135 matched papers (92 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
135
135 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
135 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
92 in the last 10 years · high confidence · 65.1th percentile (publications denominator)
Phrase hits: 135 · MeSH hits: 0
Who's working on it?
629
Distinct author names in 135 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Adamus G4 papers · 2018
Ocular Immunology Laboratory, Casey Eye Institute, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Papers in Europe PMC - 02Miles SL4 papers · 2023
Department of Biomedical Sciences, Toxicology Research Cluster, Joan C. Edwards School of Medicine, Marshall University, 1700 Third Avenue, Huntington, West Virginia 25755, United States.
Papers in Europe PMC - 03Pulido JS4 papers · 2015
Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Papers in Europe PMC - 04De Salvo G3 papers · 2025
Southampton Eye Unit, University Hospital Southampton, 103 Tremona Rd, Southampton, SO16 6HU, UK. gabrielladesalvo@gmail.com.
Papers in Europe PMC - 05Lotery AJ3 papers · 2025
Southampton Eye Unit, University Hospital Southampton, 103 Tremona Rd, Southampton, SO16 6HU, UK.
Papers in Europe PMC - 06Rahimy E3 papers · 2019
Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania.
Papers in Europe PMC - 07Winters JL3 papers · 2013Papers in Europe PMC
- 08Afshar F2 papers · 2025
Southampton Eye Unit, University Hospital Southampton, 103 Tremona Rd, Southampton, SO16 6HU, UK.
Papers in Europe PMC - 09Agrawal R2 papers · 2022
Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. rupesh.agrawal@moorfields.nhs.uk.
Papers in Europe PMC - 10Androudi S2 papers · 2025
Department of Ophthalmology, University of Thessaly, Larissa, Greece.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Bilateral diffuse uveal melanocytic proliferation disease" OR "BDUMP" OR "Paraneoplastic uveal melanocytic hyperplasia"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Bilateral diffuse uveal melanocytic proliferation disease" OR "BDUMP" OR "Paraneoplastic uveal melanocytic hyperplasia"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T20:22:28.261Z