ORPHA:673538
Littoral cell hemangioma of the spleen
Also known as: LCA · Littoral cell angioma · Littoral cell haemangioma of the spleen
Publications
323
72.1th percentile
Trials
0
Interventional, condition-specific
Researchers
1,035
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
323 matched papers (137 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
323
323 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
323 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
137 in the last 10 years · medium confidence · 72.1th percentile (publications denominator)
Phrase hits: 323 · MeSH hits: 0
Who's working on it?
1,035
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Wang X4 papers · 2026
Yun-Qiang Cai, Xing Wang, Xun Ran, Xu-Bao Liu, Bing Peng, Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Papers in Europe PMC - 02Wang J3 papers · 2024
From the Department of Radiology, the First Affiliated Hospital, College of Medicine, Jiaxing University.
Papers in Europe PMC - 03Wang L3 papers · 2024
From the Department of Radiology, the First Affiliated Hospital, College of Medicine, Jiaxing University.
Papers in Europe PMC - 04Zhang Y3 papers · 2022
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Papers in Europe PMC - 05Zhou X3 papers · 2023
Department of Pathology, Jinling Hospital of Southern Medical University 305 Zhongshan East Road, Nanjing 210002, Jiangsu, China.
Papers in Europe PMC - 06Al-Hawary MM2 papers · 2014Papers in Europe PMC
- 07Arber DA2 papers · 2021
Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address: darber1@bsd.uchicago.edu.
Papers in Europe PMC - 08Auerbach A2 papers · 2022
From the Department of Pathology, Walter Reed National Military Medical Center, Bethesda Maryland (Dr Borch); the Department of Hematopathology, University of Virginia, Charlottesville (Dr Aguilera); the Department of Hematopathology, Joint Pathology Center, Silver Spring, Maryland (Drs Brissette and Auerbach); and the Department of Hematopathology, NeoGenomics, Aliso Viejo, California (Dr O'Malley).
Papers in Europe PMC - 09Cai G2 papers · 2011Papers in Europe PMC
- 10Cai W2 papers · 2026
Department of Hepatobiliary Surgery, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Littoral cell hemangioma of the spleen" OR "Littoral cell hemangioma of spleen" OR "Littoral cell angioma" OR "Littoral cell haemangioma of the spleen" OR "Littoral cell haemangioma of spleen"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Littoral cell hemangioma of the spleen" OR "Littoral cell hemangioma of spleen" OR "Littoral cell angioma" OR "Littoral cell haemangioma of the spleen" OR "Littoral cell haemangioma of spleen"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: LCA
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T20:18:53.140Z