ORPHA:66624
PANDAS
Also known as: Pediatric autoimmune disorders associated with Streptococcus infections · Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections
Publications
24,631
Trials
5
Interventional, condition-specific
Researchers
907
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0019020
- MeSH:C537163
- UMLS:C2931429
Additional Mondo synonyms (4)
paediatric autoimmune disorders associated with Streptococcus infections · paediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections · pediatric autoimmune disorders associated with Streptococcus infections · pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
24,631 matched papers (23,228 in last 10 years) Source
- Phenotype characterisedPresent
24 HPO annotations (e.g. Tics; Oppositional defiant disorder; Anorexia) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
5 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
24
Associated phenotypes · MONDO:0019020
- Tics
- Oppositional defiant disorder
- Anorexia
- Phonophobia
- Recurrent streptococcus pneumoniae infections
Showing 5 of 24 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
24,631
24,631 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
24,631 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
23,228 in the last 10 years · low confidence
Phrase hits: 24,629 · MeSH hits: 22
Who's working on it?
907
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Hou R21 papers · 2026
Chengdu Research Base of Giant Panda Breeding, Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, 610081, China.
Papers in Europe PMC - 02Li D19 papers · 2026
Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in the Giant Panda National Park, China Conservation and Research Center for the Giant Panda, Chengdu, China.
Papers in Europe PMC - 03Li Y16 papers · 2026
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Sciences and Technology, Foshan University, Foshan, China.
Papers in Europe PMC - 04Li C14 papers · 2026
China Conservation and Research Center for the Giant Panda, Chengdu, Sichuan, China.
Papers in Europe PMC - 05Zhou Y14 papers · 2026
Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan, China.
Papers in Europe PMC - 06Liu J11 papers · 2026
Center for Systems Integration and Sustainability, Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA. liuji@msu.edu.
Papers in Europe PMC - 07Liu S11 papers · 2026
Chengdu Research Base of Giant Panda Breeding, Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, 610081, China, srui_liu@163.com.
Papers in Europe PMC - 08Liu Y11 papers · 2026
School of Grassland Science, Beijing Forestry University, Beijing, China.
Papers in Europe PMC - 09Wang J11 papers · 2026
Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu, 610064, China.
Papers in Europe PMC - 10Yang X10 papers · 2026
Sichuan Station of Protected Area Management, Chengdu, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
5
interventional trials for this specific condition
5 interventional trials matched this specific condition name; none in our sample are currently recruiting.
Data as of 11 September 2026
5 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 89.2th percentile).
low confidence · 89.2th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
5 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Observational and natural-history studies
6 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06811935·RECRUITING·PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study
Not reviewed·Conditions: PANS · PANDAS·Matched via name phrase
- NCT02889016·RECRUITING·Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS
Not reviewed·Conditions: Pediatric Acute-Onset Neuropsychiatric Syndrome · Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections · PANS · PANDAS·Matched via name + MeSH
- NCT04806620·RECRUITING·Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
Not reviewed·Conditions: Post-Acute COVID-19 Syndrome · ME/CFS · Rheumatic Arthritis · Juvenile Rheumatoid Arthritis (JRA)·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 2 · after dedupe 2 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 2 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (2)
- ctis·2026-525355-93-00·Authorised·PHASE III, OPEN-LABEL, RANDOMIZED, CONTROLLED, NON-INFERIORITY CLINICAL-TRIAL TO ASSESS THE EFFICACY AND SAFETY OF SHORT OUTPATIENT AMOXICILLIN REGIMENS IN CHILDREN WITH ACUTE STREPTOCOCCAL PHARYNGOTONSILLITIS (STOP – TRIAL)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN14842077·No longer recruiting·A patient decision aid to improve decision quality and health outcome in type 2 diabetic patients
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for PANDAS — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"PANDAS" OR "Pediatric autoimmune disorders associated with Streptococcus infections" OR "Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections" OR "paediatric autoimmune disorders associated with Streptococcus infections" OR "paediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections"
MeSH descriptor terms unioned into the query: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"PANDAS" OR "Pediatric autoimmune disorders associated with Streptococcus infections" OR "Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections" OR "paediatric autoimmune disorders associated with Streptococcus infections" OR "paediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections" OR "Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections"
Interventional trials matched via: phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 5 interventional · 6 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (24631) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T01:20:50.802Z