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ORPHA:66529

Tako-Tsubo cardiomyopathy

low confidenceDisorder

Also known as: Ampulla cardiomyopathy · Apical ballooning syndrome · Ballooning cardiomyopathy · Broken heart syndrome · Stress cardiomyopathy · Tako-Tsubo syndrome · Takotsubo cardiomyopathy · Takotsubo syndrome · Transient left ventricular apical ballooning syndrome

Publications

15,855

Trials

22

Interventional, condition-specific

Researchers

1,087

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS).

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (7)

Takotsubo Cardiomyopathy · ampulla cardiomyopathy · apical ballooning syndrome · ballooning cardiomyopathy · broken heart syndrome · stress cardiomyopathy · transient left ventricular apical ballooning syndrome

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    15,855 matched papers (11,089 in last 10 years) Source

  3. Phenotype characterisedPresent

    37 HPO annotations (e.g. Hypertension; Prolonged QT interval; Prolonged QTc interval) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    22 matched on ClinicalTrials.gov (8 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

37

Associated phenotypes · MONDO:0019018

  • Hypertension
  • Prolonged QT interval
  • Prolonged QTc interval
  • Decreased QRS voltage
  • Mitral regurgitation

Showing 5 of 37 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

7

Drugs / clinical candidates · MONDO_0019018

CTD chemicals (MyDisease.info)

15 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Dobutamine · therapeutic
  • Metoprolol · therapeutic
  • Amphetamine · marker/mechanism
  • Catecholamines · marker/mechanism
  • Cocaine · marker/mechanism
  • Dipyridamole · marker/mechanism
  • Disopyramide · marker/mechanism
  • Epinephrine · marker/mechanism
  • Fluorouracil · marker/mechanism
  • Ketamine · marker/mechanism
  • lumiracoxib · marker/mechanism
  • Nasal Decongestants · marker/mechanism

MyDisease.info · MONDO:0019018

Literature

Is anyone studying this?

15,855

15,855 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

15,855 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

11,089 in the last 10 years · low confidence

Phrase hits: 15,855 · MeSH hits: 214

Open Europe PMC search

Who's working on it?

1,087

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Arcari L8 papers · 2026

    Cardiology Unit, Madre Giuseppina Vannini Hospital, Rome, Italy; Department of General Surgery and Surgical Speciality Paride Stefanini, Sapienza University of Rome, Rome, Italy. Electronic address: luca.arcari88@gmail.com.

    Papers in Europe PMC
  2. 02
    Cacciotti L5 papers · 2026

    Cardiology Unit, Madre Giuseppina Vannini Hospital, Rome, Italy. Electronic address: lcuccc@libero.it.

    Papers in Europe PMC
  3. 03
    Cau R4 papers · 2026

    Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy.

    Papers in Europe PMC
  4. 04
    Ciolina F4 papers · 2026

    Cardiology Unit, Madre Giuseppina Vannini Hospital, Rome, Italy.

    Papers in Europe PMC
  5. 05
    Eitel I4 papers · 2026

    Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research (DZHK), University Heart Center Lübeck, partner site Hamburg/Kiel/Lübeck, Lübeck, Germany. Electronic address: ingo.eitel@uksh.de.

    Papers in Europe PMC
  6. 06
    Galea N4 papers · 2026

    Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

    Papers in Europe PMC
  7. 07
    Liu K4 papers · 2026

    Division of Cardiology, Heart and Vascular Center, Washington University in St Louis, Barnes Jewish Hospital, St Louis 63110, MO, United States of America.

    Papers in Europe PMC
  8. 08
    Marchetti MF4 papers · 2026

    Clinical Cardiology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

    Papers in Europe PMC
  9. 09
    Montisci R4 papers · 2026

    Clinical Cardiology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

    Papers in Europe PMC
  10. 10
    Pontone G4 papers · 2026

    Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

22

interventional trials for this specific condition

22 interventional trials matched this specific condition name; 8 currently recruiting in our sample. 704 trials are registered for cardiomyopathy, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

22 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.2th percentile).

low confidence · 95.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

22 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: cardiomyopathy

704

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

36 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Tako-Tsubo cardiomyopathy — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Tako-Tsubo cardiomyopathy" OR "Ampulla cardiomyopathy" OR "Apical ballooning syndrome" OR "Ballooning cardiomyopathy" OR "Broken heart syndrome" OR "Stress cardiomyopathy" OR "Tako-Tsubo syndrome" OR "Takotsubo cardiomyopathy" OR "Takotsubo syndrome" OR "Transient left ventricular apical ballooning syndrome"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Takotsubo Cardiomyopathy

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Tako-Tsubo cardiomyopathy" OR "Ampulla cardiomyopathy" OR "Apical ballooning syndrome" OR "Ballooning cardiomyopathy" OR "Broken heart syndrome" OR "Stress cardiomyopathy" OR "Tako-Tsubo syndrome" OR "Takotsubo cardiomyopathy" OR "Takotsubo syndrome" OR "Transient left ventricular apical ballooning syndrome"

Interventional trials matched via: both, phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 22 interventional · 36 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"cardiomyopathy"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (15855) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T01:20:36.272Z