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ORPHA:662721

Placenta accreta spectrum disorder

low confidenceDisorder

Also known as: AIP · Abnormally invasive placenta · PAI · PAS · Placenta accreta spectrum

Publications

3,458

Trials

66

Interventional, condition-specific

Researchers

1,095

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare disorder related with pregnancy characterized by an abnormally invasive placenta that fails to detach spontanously from the uterine wall during delivery. Placenta that partially or totally attached to uterine wall, risk to cause massive and life-threatening bleeding if forced to remove. diagnosis is essential, however difficult, to reduce maternal and fetal morbidity. Major risk factors are uterine surgery and uterine scar secondary to cesarean delivery.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    3,458 matched papers (3,358 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    66 matched on ClinicalTrials.gov (15 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

1 associated chemical. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Cocaine · marker/mechanism

MyDisease.info · MONDO:0005916

Literature

Is anyone studying this?

3,458

3,458 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

3,458 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

3,358 in the last 10 years · low confidence

Phrase hits: 3,315 · MeSH hits: 238

Open Europe PMC search

Who's working on it?

1,095

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Einerson BD10 papers · 2025

    Department of Obstetrics and Gynecology (Drs Givens and Einerson), University of Utah Health (UUH), Salt Lake City, Utah, USA.

    Papers in Europe PMC
  2. 02
    Jauniaux E9 papers · 2026

    Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London (UCL), London, UK.

    Papers in Europe PMC
  3. 03
    Shamshirsaz AA9 papers · 2026

    Department of Obstetrics and Gynecology, Baylor College of Medicine, Texas Children's Fetal Center, Houston, TX 77030, USA.

    Papers in Europe PMC
  4. 04
    Bartels HC7 papers · 2026

    Department of UCD Obstetrics and Gynecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin 2, Ireland.

    Papers in Europe PMC
  5. 05
    Silver RM7 papers · 2025

    Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT.

    Papers in Europe PMC
  6. 06
    Afshar Y6 papers · 2026

    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

    Papers in Europe PMC
  7. 07
    Hobson SR6 papers · 2026

    Department of Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST) at Toronto Metropolitan University, Canada; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada.

    Papers in Europe PMC
  8. 08
    Matsuzaki S6 papers · 2026

    Department of Obstetrics and Gynecology, Osaka General Medical Center, Osaka 558-8558, Japan.

    Papers in Europe PMC
  9. 09
    Munoz JL6 papers · 2026

    Department of Obstetrics and Gynecology, Baylor College of Medicine, Texas Children's Fetal Center, Houston, TX 77030, USA.

    Papers in Europe PMC
  10. 10
    Nieto-Calvache AJ6 papers · 2026

    Departamento de Ginecología y Obstetricia, Fundación Valle del Lili, Clínica de Espectro de Acretismo Placentario, Cra 98 No. 18-49, Cali, 760032, Colombia. albaro.nieto@fvl.org.co.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

66

interventional trials for this specific condition

66 interventional trials matched this specific condition name; 15 currently recruiting in our sample.

Data as of 11 September 2026

66 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 97.9th percentile).

low confidence · 97.9th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

66 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

71 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 7 · after dedupe 7 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 7 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (7)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Placenta accreta spectrum disorder — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Placenta accreta spectrum disorder" OR "Abnormally invasive placenta" OR "Placenta accreta spectrum"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Placenta Accreta

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Placenta accreta spectrum disorder" OR "Abnormally invasive placenta" OR "Placenta accreta spectrum" OR "Placenta Accreta"

Interventional trials matched via: both, phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 66 interventional · 71 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: AIP; PAI; PAS

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 3 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (3458) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T20:13:13.527Z