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ORPHA:658917

Clonorchiasis

low confidenceDisorder

Publications

3,475

Trials

1

Interventional, condition-specific

Researchers

921

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare parasitic disease characterized by infection with the trematode Clonorchis sinensis (Chinese or oriental liver fluke) through ingestion of metacercarial cysts via infected raw or undercooked fish. Clinical symptoms are related to worm burden. Most acute infections are asymptomatic or present with mild abdominal symptoms. Patients with high worm burdens experience fever, headache, right upper-quadrant abdominal pain, and intermittent colic pain caused by the worms obstructing the gallbladder. Chronic infections are usually severe, resulting in fibrosis of small bile ducts and destruction of the adjacent liver parenchyma, and strongly associated with cholangiocarcinoma.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (1)

Oriental liver fluke disease

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    3,475 matched papers (1,464 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

3,475

3,475 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

3,475 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

1,464 in the last 10 years · low confidence

Phrase hits: 3,475 · MeSH hits: 137

Open Europe PMC search

Who's working on it?

921

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li X19 papers · 2026

    Central Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

    Papers in Europe PMC
  2. 02
    Zhang X17 papers · 2026

    Department of Parasitology, Harbin Medical University, Harbin, China.

    Papers in Europe PMC
  3. 03
    Ding J12 papers · 2026

    Department of Parasitology, Harbin Medical University, Harbin, China.

    Papers in Europe PMC
  4. 04
    Qian MB12 papers · 2026

    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai, China. ahtlqmb-007@163.com.

    Papers in Europe PMC
  5. 05
    Han S10 papers · 2026

    Jiangnan University Medical Center, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  6. 06
    Li J10 papers · 2026

    Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China.

    Papers in Europe PMC
  7. 07
    Chen R9 papers · 2026

    Jiangnan University Medical Center, Jiangnan University, Wuxi, China.

    Papers in Europe PMC
  8. 08
    Li S9 papers · 2025

    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.

    Papers in Europe PMC
  9. 09
    Chen J8 papers · 2026

    Department of Pediatric Surgery, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.

    Papers in Europe PMC
  10. 10
    Hong SJ8 papers · 2025

    Department of Medical Sciences, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; 1 currently recruiting in our sample.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

low confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Clonorchiasis" OR "Oriental liver fluke disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Clonorchiasis

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Clonorchiasis" OR "Oriental liver fluke disease"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (3475) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T20:05:41.283Z