RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:652658

Monomorphic epitheliotropic intestinal T-cell lymphoma

high confidenceDisorder

Also known as: Enteropathy-associated T-cell lymphoma type 2 · MEITL

Publications

540

89.7th percentile

Trials

8

Interventional, condition-specific

Researchers

1,370

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare T-cell non-Hodgkin lymphoma characterized by monomorphic cytomorphology and epitheliotropism. It is mostly detected in the small intestine but can also be present in the colon, duodenum and stomach. It is an aggressive tumor that can disseminate to mesenteric lymph nodes, lung, liver, brain and skin. Major clinical features include abdominal pain, gastrointestinal bleeding, obstruction or perforation, diarrhoea, and weight loss. It is not associated to coeliac disease.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    540 matched papers (470 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    8 matched on ClinicalTrials.gov (2 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

540

540 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

540 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

470 in the last 10 years · high confidence · 89.7th percentile (publications denominator)

Phrase hits: 540 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,370

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    de Leval L11 papers · 2026

    Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Laurence.deleval@chuv.ch.

    Papers in Europe PMC
  2. 02
    Gaulard P11 papers · 2026

    Department of Pathology, AP-HP, Henri Mondor Hospital, F-94010, Créteil, France.

    Papers in Europe PMC
  3. 03
    Zhang Y10 papers · 2026

    Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.

    Papers in Europe PMC
  4. 04
    Drieux F7 papers · 2026

    Centre Henri Becquerel, Service of Anatomical and Cytological Pathology, Centre Henri Becquerel, Rouen, France.

    Papers in Europe PMC
  5. 05
    Lemonnier F7 papers · 2026

    University Paris Est Créteil, INSERM, IMRB, Créteil, France.

    Papers in Europe PMC
  6. 06
    Liu Y7 papers · 2026

    Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY.

    Papers in Europe PMC
  7. 07
    Chuang SS6 papers · 2026

    Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: cmh5301@mail.chimei.org.tw.

    Papers in Europe PMC
  8. 08
    Fataccioli V6 papers · 2026

    Department of Pathology, AP-HP, Henri Mondor Hospital, F-94010, Créteil, France.

    Papers in Europe PMC
  9. 09
    Missiaglia E6 papers · 2026

    Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

    Papers in Europe PMC
  10. 10
    Poullot E6 papers · 2026

    Department of Pathology, AP-HP, Henri Mondor Hospital, F-94010, Créteil, France.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

8

interventional trials for this specific condition

8 interventional trials matched this specific condition name; 2 currently recruiting in our sample.

Data as of 27 July 2026

8 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 90.6th percentile).

high confidence · 90.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

8 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Monomorphic epitheliotropic intestinal T-cell lymphoma" OR "Enteropathy-associated T-cell lymphoma type 2" OR "MEITL"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Monomorphic epitheliotropic intestinal T-cell lymphoma" OR "Enteropathy-associated T-cell lymphoma type 2" OR "MEITL"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 8 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T19:57:24.608Z