ORPHA:647823
Idiopathic pregnancy-associated osteoporosis
Also known as: PLO · Pregnancy and lactation-associated osteoporosis · Pregnancy induced osteoporosis · Idiopathic premenopausal osteoporosis associated with pregnancy · Osteoporosis of pregnancy · PAO
Publications
1,448
Trials
0
Interventional, condition-specific
Researchers
1,020
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0957481
- UMLS:C5782297
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,448 matched papers (1,085 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,448
1,448 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,448 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,085 in the last 10 years · low confidence
Phrase hits: 1,448 · MeSH hits: 0
Who's working on it?
1,020
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Cohen A9 papers · 2026
Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA.
Papers in Europe PMC - 02Bucovsky M6 papers · 2026
Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA.
Papers in Europe PMC - 03Colon I6 papers · 2026
Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA.
Papers in Europe PMC - 04Kamanda-Kosseh M6 papers · 2026
Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA.
Papers in Europe PMC - 05Shane E6 papers · 2026
Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA.
Papers in Europe PMC - 06Hadji P5 papers · 2026
Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.
Papers in Europe PMC - 07Huang W5 papers · 2025
Department of Occupation and Environmental Health, Peking University School of Public Health, Peking University Institute of Environmental Medicine, Peking University, Beijing, China whuang@bjmu.edu.cn angela-yy65@hotmail.com.
Papers in Europe PMC - 08Kovacs CS5 papers · 2026
Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
Papers in Europe PMC - 09Qian Y5 papers · 2024
Endocrinology Department, 960 Hospital of People's Liberation Army, NO.25 Shifan Road, Jinan, Shandong, 250031, People's Republic of China.
Papers in Europe PMC - 10Wang J5 papers · 2026
School of Atmospheric Sciences, Nanjing University, Nanjing, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 5 observational studies did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
Broader category pregnancy associated osteoporosis also has no matched interventional trial. See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Broader category: pregnancy associated osteoporosis
0
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Parent-category matching found a broader label but no interventional trials under it. How we count trials.
Observational and natural-history studies
5 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT03598361·RECRUITING·Mineral Status in Pregnant Women
Conditions: Pregnancy; Disorder, Blood·Matched via recall expansion
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic pregnancy-associated osteoporosis" OR "Pregnancy and lactation-associated osteoporosis" OR "Pregnancy induced osteoporosis" OR "Idiopathic premenopausal osteoporosis associated with pregnancy" OR "Osteoporosis of pregnancy" OR "Osteoporosis of the pregnancy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic pregnancy-associated osteoporosis" OR "Pregnancy and lactation-associated osteoporosis" OR "Pregnancy induced osteoporosis" OR "Idiopathic premenopausal osteoporosis associated with pregnancy" OR "Osteoporosis of pregnancy" OR "Osteoporosis of the pregnancy" OR "pregnancy disorder"
Recall-expansion terms: pregnancy disorder
Study-type breakdown: 0 interventional · 5 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"pregnancy associated osteoporosis"
Query health: ok — strategies attempted: phrase, recall-expansion; with hits: phrase, recall-expansion
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: PLO; PAO
Confidence reasoning
- Preferred label is multi-word and distinctive
- 2 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (1448) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-27T19:49:19.594Z