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ORPHA:645814

Primary pulmonary tuberculosis

high confidenceSubtype of disorder

Also known as: Tuberculosis of respiratory system

Publications

707

62.6th percentile

Trials

0

Interventional, condition-specific

Researchers

1,001

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    707 matched papers (143 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPartial

    None under the specific name; 158 for broader category pulmonary tuberculosis

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

707

707 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

707 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

143 in the last 10 years · high confidence · 62.6th percentile (publications denominator)

Phrase hits: 707 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,001

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Andronikou S8 papers · 2025

    Department of Paediatric Radiology, Red Cross Children's Hospital, Klipfontein Road, Rondebosch, Cape Town, South Africa. docsav@mweb.co.za

    Papers in Europe PMC
  2. 02
    Zhang X8 papers · 2024

    1 Nanjing Chest Hospital, Nanjing 210029, China ; 2 The Fifth People's Hospital of Suzhou, Suzhou 215000, China ; 3 The Third People's Hospital of Changzhou, Changzhou 213000, China ; 4 The Third People's Hospital of Zhenjiang, Zhenjiang 215005, China ; 5 The Fifth People's Hospital of Wuxi, Wuxi 214000, China ; 6 The Sixth People's Hospital of Nantong, Nantong 226011, China ; 7 The Fourth People's Hospital of Huai'an, Huai'an 223002, China ; 8 Xuzhou Infectious Disease Hospital, Xuzhou 221000, China ; 9 The Second People's Hospital of Changshu, Changshu 215500, China ; 10 The Second People's Hospital of Yancheng, Yancheng 224002, China ; 11 The Third People's Hospital of Yangzhou, Yangzhou 225000, China ; 12 Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu 610041, China.

    Papers in Europe PMC
  3. 03
    Goussard P5 papers · 2025

    Department of Paediatrics and Child Health, Tygerberg Hospital and the University of Stellenbosch, Cape Town, South Africa.

    Papers in Europe PMC
  4. 04
    Wang Y5 papers · 2024

    Shanghai Jiao Tong University, Shanghai, China. wangyanfeng622@sjtu.edu.cn.

    Papers in Europe PMC
  5. 05
    Liu Z4 papers · 2025

    Department of Tuberculosis, Jiangxi Chest Hospital, Nanchang 330006, Jiangxi, China

    Papers in Europe PMC
  6. 06
    He Y3 papers · 2025

    Department of Tuberculosis, The Fourth People's Hospital of Nanning City, Nanning, People's Republic of China.

    Papers in Europe PMC
  7. 07
    Li L3 papers · 2023

    Cadre Ward 2, Bethune International Peace Hospital, Shijiazhuang, Hebei, P.R. China.

    Papers in Europe PMC
  8. 08
    Liu J3 papers · 2023

    Department of Respiratory Medicine, Hebei Chest Hospital, Shijiazhuang, Hebei, P.R. China.

    Papers in Europe PMC
  9. 09
    Madhi SA3 papers · 2023

    South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa; Faculty of Health Science, National Research Foundation: Vaccine Preventable Diseases, Department of Science, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: shabir.madhi@wits.ac.za.

    Papers in Europe PMC
  10. 10
    Moore DP3 papers · 2023

    South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 158 trials are registered for pulmonary tuberculosis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 9 September 2026 · last trial check 9 September 2026

No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.

high confidence · 38.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

158 interventional trials matched pulmonary tuberculosis, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: pulmonary tuberculosis

158

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 65 · after dedupe 65 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 65 · dropped 0 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (65)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Primary pulmonary tuberculosis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Primary pulmonary tuberculosis" OR "Tuberculosis of respiratory system"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Primary pulmonary tuberculosis" OR "Tuberculosis of respiratory system" OR "Tuberculosis of the respiratory system"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"pulmonary tuberculosis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T01:38:51.359Z